Next Article in Journal
Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor
Previous Article in Journal
Novel and Efficient Synthesis of Phenethyl Formate via Enzymatic Esterification of Formic Acid
Previous Article in Special Issue
A Novel View of Human Helicobacter pylori Infections: Interplay between Microbiota and Beta-Defensins
Open AccessArticle

An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome

1
Institute of Traditional Medicine and Bioscience, Dunsan Hospital of Daejeon University, Daejeon 34323, Korea
2
Korean Medical College of Daejeon University, 62, Daehak-ro, Dong-gu, Daejeon 34323, Korea
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 71; https://doi.org/10.3390/biom10010071 (registering DOI)
Received: 10 December 2019 / Revised: 24 December 2019 / Accepted: 29 December 2019 / Published: 1 January 2020
(This article belongs to the Special Issue Inflammation as Target treatment for Chronic Diseases)
Chronic fatigue syndrome (CFS) is one of the most intractable diseases and is characterized by severe central fatigue that impairs even daily activity. To date, the pathophysiological mechanisms are uncertain and no therapies exist. Therefore, a proper animal model reflecting the clinical features of CFS is urgently required. We compared two CFS animal models most commonly used, by injection with lipopolysaccharide (LPS from Escherichia coli O111:B4) or polyinosinic: polycytidylic acid (poly I:C), along with bilateral adrenalectomy (ADX) as another possible model. Both LPS- and poly I:C-injected mice dominantly showed depressive behaviors, while ADX led to fatigue-like performances with high pain sensitivity. In brain tissues, LPS injection notably activated microglia and the 5-hydroxytryptamine (HT)1A receptor in the prefrontal cortex and hippocampus. Poly I:C-injection also remarkably activated the 5-HT transporter and 5-HT1A receptor with a reduction in serotonin levels in the brain. ADX particularly activated astrocytes and transforming growth factor beta (TGF-β) 1 in all brain regions. Our results revealed that LPS and poly I:C animal models approximate depressive disorder more closely than CFS. We suggest that ADX is a possible method for establishing a mouse model of CFS reflecting clinical features, especially in neuroendocrine system. View Full-Text
Keywords: chronic fatigue syndrome; animal model; lipopolysaccharide; polyinosinic: polycytidylic acid; adrenalectomy chronic fatigue syndrome; animal model; lipopolysaccharide; polyinosinic: polycytidylic acid; adrenalectomy
Show Figures

Graphical abstract

MDPI and ACS Style

Lee, J.-S.; Jeon, Y.-J.; Park, S.-Y.; Son, C.-G. An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome. Biomolecules 2020, 10, 71.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop