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Open AccessReview

Generation of Retinaldehyde for Retinoic Acid Biosynthesis

1
Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
2
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 5; https://doi.org/10.3390/biom10010005
Received: 16 November 2019 / Revised: 14 December 2019 / Accepted: 16 December 2019 / Published: 18 December 2019
(This article belongs to the Special Issue Retinoids in Embryonic Development)
The concentration of all-trans-retinoic acid, the bioactive derivative of vitamin A, is critically important for the optimal performance of numerous physiological processes. Either too little or too much of retinoic acid in developing or adult tissues is equally harmful. All-trans-retinoic acid is produced by the irreversible oxidation of all-trans-retinaldehyde. Thus, the concentration of retinaldehyde as the immediate precursor of retinoic acid has to be tightly controlled. However, the enzymes that produce all-trans-retinaldehyde for retinoic acid biosynthesis and the mechanisms responsible for the control of retinaldehyde levels have not yet been fully defined. The goal of this review is to summarize the current state of knowledge regarding the identities of physiologically relevant retinol dehydrogenases, their enzymatic properties, and tissue distribution, and to discuss potential mechanisms for the regulation of the flux from retinol to retinaldehyde. View Full-Text
Keywords: retinoic acid; retinol; retinaldehyde; short-chain dehydrogenase; vitamin A; retinol dehydrogenase; retinaldehyde reductase; embryogenesis retinoic acid; retinol; retinaldehyde; short-chain dehydrogenase; vitamin A; retinol dehydrogenase; retinaldehyde reductase; embryogenesis
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Belyaeva, O.V.; Adams, M.K.; Popov, K.M.; Kedishvili, N.Y. Generation of Retinaldehyde for Retinoic Acid Biosynthesis. Biomolecules 2020, 10, 5.

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