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Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

1
Grigore T. Popa” University of Medicine and Pharmacy, Center for Advanced Research and Development in Experimental Medicine (CEMEX), 16 Universitatii street, 700115 Iasi, Romania
2
Grigore T. Popa” University of Medicine and Pharmacy, Pneumology Department, 16 Universitatii Street, 700115 Iasi, Romania
3
Grigore T. Popa” University of Medicine and Pharmacy, Pharmacodynamics and Clinical Pharmacy Department, 16 Universitatii street, 700115 Iasi, Romania
4
University of Agricultural Sciences and Veterinary Medicine “Ion Ionescu de la Brad”, Faculty of Veterinary Medicine, 8 M. Sadoveanu Alley, 700489 Iasi, Romania
5
Grigore T. Popa” University of Medicine and Pharmacy, Department of Physiology, 16 Universitatii street, 700115 Iasi, Romania
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(1), 40; https://doi.org/10.3390/biom10010040
Received: 29 November 2019 / Revised: 20 December 2019 / Accepted: 24 December 2019 / Published: 26 December 2019
(This article belongs to the Special Issue Cholinesterases in Alzheimer's Disease)
Alzheimer’s disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning. The etiology of this disease is not completely understood, and no safe and effective anti-Alzheimer’s disease drug to prevent, stop, or reverse its evolution is currently available. Current pharmacotherapy concentrated on drugs that aimed to improve the cerebral acetylcholine levels by facilitating cholinergic neurotransmission through inhibiting cholinesterase. These compounds, recognized as cholinesterase inhibitors, offer a viable target across key sign domains of Alzheimer’s disease, but have a modest influence on improving the progression of this condition. In this paper, we sought to highlight the current understanding of the cholinergic system involvement in Alzheimer’s disease progression in relation to the recent status of the available cholinesterase inhibitors as effective therapeutics. View Full-Text
Keywords: Alzheimer’s disease; cholinergic system; cholinesterase inhibitors; acetylcholinesterase; butyrylcholinesterase Alzheimer’s disease; cholinergic system; cholinesterase inhibitors; acetylcholinesterase; butyrylcholinesterase
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MDPI and ACS Style

Stanciu, G.D.; Luca, A.; Rusu, R.N.; Bild, V.; Beschea Chiriac, S.I.; Solcan, C.; Bild, W.; Ababei, D.C. Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement. Biomolecules 2020, 10, 40. https://doi.org/10.3390/biom10010040

AMA Style

Stanciu GD, Luca A, Rusu RN, Bild V, Beschea Chiriac SI, Solcan C, Bild W, Ababei DC. Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement. Biomolecules. 2020; 10(1):40. https://doi.org/10.3390/biom10010040

Chicago/Turabian Style

Stanciu, Gabriela D.; Luca, Andrei; Rusu, Razvan N.; Bild, Veronica; Beschea Chiriac, Sorin I.; Solcan, Carmen; Bild, Walther; Ababei, Daniela C. 2020. "Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement" Biomolecules 10, no. 1: 40. https://doi.org/10.3390/biom10010040

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