Next Article in Journal
Simultaneous Synthesis of Vitamins D2, D4, D5, D6, and D7 from Commercially Available Phytosterol, β-Sitosterol, and Identification of Each Vitamin D by HSQC NMR
Previous Article in Journal
Exo-Metabolites of Phaseolus vulgaris-Nodulating Rhizobial Strains
Conference Report

Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium

1
Gunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi 371-8510, Japan
2
Division of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna 171 77, Sweden
3
Senator Frank R Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Division of Environmental Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4
National Center for the Japan Environment and Children’s Study, National Institute for Environmental Sciences, Tsukuba 305-0053, Japan
5
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
6
Department of Pharmacology, University of California, San Diego, CA 92093, USA
7
Institute of Environmental Medicine, Karolinska Institutet, Solna 171 77, Sweden
8
Department of Clinical Sciences and Education, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm 118 83, Sweden
9
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10027, USA
10
Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore 117597, Singapore
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(6), 106; https://doi.org/10.3390/metabo9060106
Received: 22 April 2019 / Revised: 18 May 2019 / Accepted: 3 June 2019 / Published: 6 June 2019
The attempt to describe complex diseases by solely genetic determination has not been successful. There is increasing recognition that the development of disease is often a consequence of interactions between multiple genetic and environmental factors. To date, much of the research on environmental determinants of disease has focused on single exposures generally measured at a single time point. In order to address this limitation, the concept of the exposome has been introduced as a comprehensive approach, studying the full complement of environmental exposures from conception onwards. However, exposures are vast, dynamic, and diverse, and only a small proportion can be reasonably measured due to limitations in technology and feasibility. In addition, the interplay between genes and exposure as well as between different exposures is complicated and multifaceted, which leads to difficulties in linking disease or health outcomes with exposures. The large numbers of collected samples require well-designed logistics. Furthermore, the immense data sets generated from exposome studies require a significant computational investment for both data analysis and data storage. This report summarizes discussions during an international exposome symposium held at Gunma University in Japan regarding the concept of the exposome, challenges in exposome research, and future perspectives in the field. View Full-Text
Keywords: exposome; metabolomics; exposure; epigenetics; environment exposome; metabolomics; exposure; epigenetics; environment
Show Figures

Figure 1

MDPI and ACS Style

Zhang, P.; Arora, M.; Chaleckis, R.; Isobe, T.; Jain, M.; Meister, I.; Melén, E.; Perzanowski, M.; Torta, F.; Wenk, M.R.; Wheelock, C.E. Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium. Metabolites 2019, 9, 106. https://doi.org/10.3390/metabo9060106

AMA Style

Zhang P, Arora M, Chaleckis R, Isobe T, Jain M, Meister I, Melén E, Perzanowski M, Torta F, Wenk MR, Wheelock CE. Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium. Metabolites. 2019; 9(6):106. https://doi.org/10.3390/metabo9060106

Chicago/Turabian Style

Zhang, Pei, Manish Arora, Romanas Chaleckis, Tomohiko Isobe, Mohit Jain, Isabel Meister, Erik Melén, Matthew Perzanowski, Federico Torta, Markus R. Wenk, and Craig E. Wheelock 2019. "Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium" Metabolites 9, no. 6: 106. https://doi.org/10.3390/metabo9060106

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop