Next Article in Journal
Traceability of “Tuscan PGI” Extra Virgin Olive Oils by 1H NMR Metabolic Profiles Collection and Analysis
Previous Article in Journal
Identifying Antibacterial Compounds in Black Walnuts (Juglans nigra) Using a Metabolomics Approach
Article

A Framework for Development of Useful Metabolomic Biomarkers and Their Effective Knowledge Translation

1
Faculty of Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada
2
Department of Oncology, University of Calgary, Calgary, AB T2N 1N4, Canada
3
Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada
4
Department of Surgery, University of Calgary, Calgary, AB T2N 1N4, Canada
*
Author to whom correspondence should be addressed.
Metabolites 2018, 8(4), 59; https://doi.org/10.3390/metabo8040059
Received: 6 September 2018 / Revised: 27 September 2018 / Accepted: 28 September 2018 / Published: 30 September 2018
Despite the significant advantages of metabolomic biomarkers, no diagnostic tests based on metabolomics have been introduced to clinical use. There are many reasons for this, centered around substantial obstacles in developing clinically useful metabolomic biomarkers. Most significant is the need for interdisciplinary teams with expertise in metabolomics, analysis of complex clinical and metabolomic data, and clinical care. Importantly, the clinical need must precede biomarker discovery, and the experimental design for discovery and validation must reflect the purpose of the biomarker. Standard operating procedures for procuring and handling samples must be developed from the beginning, to ensure experimental integrity. Assay design is another challenge, as there is not much precedent informing this. Another obstacle is that it is not yet clear how to protect any intellectual property related to metabolomic biomarkers. Viewing a metabolomic biomarker as a natural phenomenon would inhibit patent protection and potentially stifle commercial interest. However, demonstrating that a metabolomic biomarker is actually a derivative of a natural phenomenon that requires innovation would enhance investment in this field. Finally, effective knowledge translation strategies must be implemented, which will require engagement with end users (clinicians and lab physicians), patient advocate groups, policy makers, and payer organizations. Addressing each of these issues comprises the framework for introducing a metabolomic biomarker to practice. View Full-Text
Keywords: metabolomics; biomarkers; knowledge translation metabolomics; biomarkers; knowledge translation
Show Figures

Figure 1

MDPI and ACS Style

Marchand, C.R.; Farshidfar, F.; Rattner, J.; Bathe, O.F. A Framework for Development of Useful Metabolomic Biomarkers and Their Effective Knowledge Translation. Metabolites 2018, 8, 59. https://doi.org/10.3390/metabo8040059

AMA Style

Marchand CR, Farshidfar F, Rattner J, Bathe OF. A Framework for Development of Useful Metabolomic Biomarkers and Their Effective Knowledge Translation. Metabolites. 2018; 8(4):59. https://doi.org/10.3390/metabo8040059

Chicago/Turabian Style

Marchand, Calena R., Farshad Farshidfar, Jodi Rattner, and Oliver F. Bathe 2018. "A Framework for Development of Useful Metabolomic Biomarkers and Their Effective Knowledge Translation" Metabolites 8, no. 4: 59. https://doi.org/10.3390/metabo8040059

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop