Next Article in Journal
The Metabolic Basis of Pollen Thermo-Tolerance: Perspectives for Breeding
Next Article in Special Issue
Micropreconcentrator in LTCC Technology with Mass Spectrometry for the Detection of Acetone in Healthy and Type-1 Diabetes Mellitus Patient Breath
Previous Article in Journal
Unraveling Biochemical Pathways Affected by Mitochondrial Dysfunctions Using Metabolomic Approaches
Previous Article in Special Issue
Chemical Analysis of Whale Breath Volatiles: A Case Study for Non-Invasive Field Health Diagnostics of Marine Mammals
Article

Evaluation of Bio-VOC Sampler for Analysis of Volatile Organic Compounds in Exhaled Breath

1
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Air Force Research Laboratory, 711th Human Performance Wing/RHXBC, Wright-Patterson AFB, OH 45433, USA
2
Air Force Research Laboratory, 711th Human Performance Wing/RHXBC, Wright-Patterson AFB, OH 45433, USA
3
UES, Air Force Research Laboratory, 711th Human Performance Wing/RHXBC, Wright-Patterson AFB, OH 45433, USA
4
Naval Medical Research Unit—Dayton, Wright-Patterson AFB, OH 45433, USA
5
Air Force Research Laboratory, 711th Human Performance Wing, U.S. Air Force School of Aerospace Medicine Wright-Patterson AFB, OH 45433, USA
*
Author to whom correspondence should be addressed.
Metabolites 2014, 4(4), 879-888; https://doi.org/10.3390/metabo4040879
Received: 16 May 2014 / Revised: 26 August 2014 / Accepted: 22 September 2014 / Published: 29 September 2014
(This article belongs to the Special Issue Breath Analysis in Metabolomics)
Monitoring volatile organic compounds (VOCs) from exhaled breath has been used to determine exposures of humans to chemicals. Prior to analysis of VOCs, breath samples are often collected with canisters or bags and concentrated. The Bio-VOC breath sampler, a commercial sampling device, has been recently introduced to the market with growing use. The main advantage for this sampler is to collect the last portion of exhaled breath, which is more likely to represent the air deep in the lungs. However, information about the Bio-VOC sampler is somewhat limited. Therefore, we have thoroughly evaluated the sampler here. We determined the volume of the breath air collected in the sampler was approximately 88 mL. When sampling was repeated multiple times, with the succeeding exhalations applied to a single sorbent tube, we observed linear relationships between the normalized peak intensity and the number of repeated collections with the sampler in many of the breath VOCs detected. No moisture effect was observed on the Tenax sorbent tubes used. However, due to the limitation in the collection volume, the use of the Bio-VOC sampler is recommended only for detection of VOCs present at high concentrations unless repeated collections of breath samples on the sampler are conducted. View Full-Text
Keywords: Bio-VOC breath sampler; volatile organic compounds (VOCs); thermal desorption; gas chromatography-mass spectrometry (GC-MS) Bio-VOC breath sampler; volatile organic compounds (VOCs); thermal desorption; gas chromatography-mass spectrometry (GC-MS)
Show Figures

Figure 1

MDPI and ACS Style

Kwak, J.; Fan, M.; Harshman, S.W.; Garrison, C.E.; Dershem, V.L.; Phillips, J.B.; Grigsby, C.C.; Ott, D.K. Evaluation of Bio-VOC Sampler for Analysis of Volatile Organic Compounds in Exhaled Breath. Metabolites 2014, 4, 879-888. https://doi.org/10.3390/metabo4040879

AMA Style

Kwak J, Fan M, Harshman SW, Garrison CE, Dershem VL, Phillips JB, Grigsby CC, Ott DK. Evaluation of Bio-VOC Sampler for Analysis of Volatile Organic Compounds in Exhaled Breath. Metabolites. 2014; 4(4):879-888. https://doi.org/10.3390/metabo4040879

Chicago/Turabian Style

Kwak, Jae, Maomian Fan, Sean W. Harshman, Catherine E. Garrison, Victoria L. Dershem, Jeffrey B. Phillips, Claude C. Grigsby, and Darrin K. Ott 2014. "Evaluation of Bio-VOC Sampler for Analysis of Volatile Organic Compounds in Exhaled Breath" Metabolites 4, no. 4: 879-888. https://doi.org/10.3390/metabo4040879

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop