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Metabolites 2012, 2(1), 1-18;

Perturbations of Lipid Metabolism Indexed by Lipidomic Biomarkers

INSERM U1057, Faculte de Medicine, “P. et M. Curie” 27 rue Chaligny, Paris 75012, France
Department of Biochemistry, King’s College London, 150 Stamford Street, London SE1 9NH, UK
Laboratory of Mass Spectrometry, Applied Lipid Investigation (APLIPID®), Paris 75012, France
Author to whom correspondence should be addressed.
Received: 28 November 2011 / Revised: 21 December 2011 / Accepted: 22 December 2011 / Published: 4 January 2012
(This article belongs to the Special Issue Lipidomics)
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The lipidome of the liver and the secreted circulating lipoproteins can now be interrogated conveniently by automated mass spectrometric methods. Multivariate analysis of the liver and serum lipid composition in various animal modes or in human patients has pointed to specific molecular species markers. The perturbations of lipid metabolism can be categorized on the basis of three basic pathological mechanisms: (1) an accelerated rate of de novo lipogenesis; (2) perturbation of the peroxisome pathway of ether-lipid and very-long-chain fatty acid biosynthesis; (3) a change in the rate of interconversion of essential omega-3 and -6 polyunsaturated fatty acids. This review provides examples to illustrate the practicalities of lipidomic studies in biomedicine. View Full-Text
Keywords: biomedical lipidomics; pharmacology; biomarkers biomedical lipidomics; pharmacology; biomarkers

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Lamaziere, A.; Wolf, C.; Quinn, P.J. Perturbations of Lipid Metabolism Indexed by Lipidomic Biomarkers. Metabolites 2012, 2, 1-18.

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