Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055

Mahnashi, Mater H.; Alshahrani, Mohammed Abdulrahman; Nahari, Mohammed H.; Hassan, Syed Shams ul; Jan, Muhammad Saeed; Ayaz, Muhammad; Ullah, Farhat; Alshehri, Osama M.; Alshehri, Mohammad Ali; Rashid, Umer; Sadiq, Abdul

doi:10.3390/metabo15080532

Open AccessCorrection

Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055

by

Mater H. Mahnashi

¹

,

Mohammed Abdulrahman Alshahrani

^2,*,

Mohammed H. Nahari

²

,

Syed Shams ul Hassan

^3,4

,

Muhammad Saeed Jan

⁵

,

Muhammad Ayaz

⁶,

Farhat Ullah

⁶,

Osama M. Alshehri

²

,

Mohammad Ali Alshehri

⁷,

Umer Rashid

^8,* and

Abdul Sadiq

^6,*

¹

Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 61441, Saudi Arabia

²

Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia

³

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

⁴

Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

⁵

Department of Pharmacy, Bacha Khan University, Charsadda 24420, KP, Pakistan

⁶

Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Dir (L), Chakdara 18000, KP, Pakistan

⁷

Medical Genetics Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia

⁸

Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, KP, Pakistan

^*

Authors to whom correspondence should be addressed.

Metabolites 2025, 15(8), 532; https://doi.org/10.3390/metabo15080532

Submission received: 18 June 2025 / Revised: 9 July 2025 / Accepted: 10 July 2025 / Published: 6 August 2025

(This article belongs to the Special Issue Identification and Therapeutic Properties of Secondary Metabolites of Medicinal Plants)

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Text Correction

There was an error in the original publication [1]. The authors request to delete Reference [83] and replace the [83] “Xu, S.; Tao, H.; Cao, W.; Cao, L.; Lin, Y.; Zhao, S.-M.; Xu, W.; Cao, J.; Zhao, J.-Y. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduct. Target. Ther. 2021, 6, 54” with Reference [61] “Wang, D.; Zhao, R.; Qu, Y.-Y.; Mei, X.-Y.; Zhang, X.; Zhou, Q.; Li, Y.; Yang, S.-B.; Zuo, Z.-G.; Chen, Y.-M.; et al. Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair. Cell Rep. 2018, 25, 398–412”.

A correction has been made to Section 4, Paragraph 6:

Free radicals are generated during metabolic processes in the body and are subsequently neutralized by natural antioxidant system like catalases and hydro-peroxidases [79,80]. However, in case of excessive free radical production or the body’s inability to scavenge the free radicals effectively, supplementation of exogenous antioxidants is extremely necessary [81]. In AD, Aβ proteins are deposited in the brain, which is considered as a mitochondrial poison. After production, it readily attacks lipids, membranes, proteins and nerve cells, causing genetic mutations, cells deterioration and the disruption of energy production by mitochondria [82]. Subsequently, supplementation of antioxidants is an integral part of the drug combinations for AD patients. Natural products and their derived compounds have received considerable attention as potential multi-target agents. Of particular interest is polyphenols which, being part of natural products and nutraceuticals, can delay the aging process and can act on multiple targets of AD. Numerous flavonoids are reported to inhibit cholinesterases, BACE1, scavenge free radicals and act as anti-inflammatory agents [61]. In the current study, our test compound showed efficacy on multiple targets and thus acts as a multi-target lead compound. However, further detailed studies regarding the bioavailability and in-vivo efficacy are required.

The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

Mahnashi, M.H.; Alshahrani, M.A.; Nahari, M.H.; Hassan, S.S.u.; Jan, M.S.; Ayaz, M.; Ullah, F.; Alshehri, O.M.; Alshehri, M.A.; Rashid, U.; et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055. [Google Scholar] [CrossRef] [PubMed]

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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MDPI and ACS Style

Mahnashi, M.H.; Alshahrani, M.A.; Nahari, M.H.; Hassan, S.S.u.; Jan, M.S.; Ayaz, M.; Ullah, F.; Alshehri, O.M.; Alshehri, M.A.; Rashid, U.; et al. Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055. Metabolites 2025, 15, 532. https://doi.org/10.3390/metabo15080532

AMA Style

Mahnashi MH, Alshahrani MA, Nahari MH, Hassan SSu, Jan MS, Ayaz M, Ullah F, Alshehri OM, Alshehri MA, Rashid U, et al. Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055. Metabolites. 2025; 15(8):532. https://doi.org/10.3390/metabo15080532

Chicago/Turabian Style

Mahnashi, Mater H., Mohammed Abdulrahman Alshahrani, Mohammed H. Nahari, Syed Shams ul Hassan, Muhammad Saeed Jan, Muhammad Ayaz, Farhat Ullah, Osama M. Alshehri, Mohammad Ali Alshehri, Umer Rashid, and et al. 2025. "Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055" Metabolites 15, no. 8: 532. https://doi.org/10.3390/metabo15080532

APA Style

Mahnashi, M. H., Alshahrani, M. A., Nahari, M. H., Hassan, S. S. u., Jan, M. S., Ayaz, M., Ullah, F., Alshehri, O. M., Alshehri, M. A., Rashid, U., & Sadiq, A. (2025). Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055. Metabolites, 15(8), 532. https://doi.org/10.3390/metabo15080532

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Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055

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