Nutri-Epigenetic Regulation of Vitamin D—Impact on Metabolism and Biological Functions: Narrative Review
Abstract
1. Introduction
2. Methods
2.1. Search Strategy
2.2. Inclusion and Exclusion Criteria
3. Development
3.1. The Influence of Intracellular Factors and Environmental Stimuli on Epigenetic Modifications
3.2. Metabolism of Vitamin D
3.3. Genetic Determinants of Vitamin D Metabolism/Key Genes Associated with Vitamin D Metabolism
3.3.1. VDR Receptor
3.3.2. NADSYN1/DHCR7
3.3.3. Vitamin D Hydroxylases
CYP2R1
CYP27A1
CYP27B1
CYP24A1
3.3.4. GC (Group-Specific Component)
3.4. Nutritional Epigenomics
3.5. Epigenetics of Vitamin D
3.5.1. Effect of Vitamin D on DNA Methylation
3.5.2. Effect of Vitamin D on Chromatin
3.5.3. Histone Modifications
3.5.4. MicroRNA
3.6. Polymorphisms of Vitamin D-Related Genes
3.6.1. VDR Gene Polymorphism
3.6.2. NADSYN1/DHCR7 Gene Polymorphism
3.6.3. CYP2R1 Gene Polymorphism
3.6.4. CYP27B1 Gene Polymorphism
3.6.5. CYP24A1 Gene Polymorphism
3.6.6. GC Gene Polymorphism
3.7. Personalisation of Vitamin D Supplementation in Response to Genetic Differences–Future Directions
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Kowalówka, M.; Górna, I.; Karaźniewicz-Łada, M.; Kusyk, D.; Przysławski, J.; Drzymała-Czyż, S. Nutri-Epigenetic Regulation of Vitamin D—Impact on Metabolism and Biological Functions: Narrative Review. Metabolites 2025, 15, 436. https://doi.org/10.3390/metabo15070436
Kowalówka M, Górna I, Karaźniewicz-Łada M, Kusyk D, Przysławski J, Drzymała-Czyż S. Nutri-Epigenetic Regulation of Vitamin D—Impact on Metabolism and Biological Functions: Narrative Review. Metabolites. 2025; 15(7):436. https://doi.org/10.3390/metabo15070436
Chicago/Turabian StyleKowalówka, Magdalena, Ilona Górna, Marta Karaźniewicz-Łada, Dominika Kusyk, Juliusz Przysławski, and Sławomira Drzymała-Czyż. 2025. "Nutri-Epigenetic Regulation of Vitamin D—Impact on Metabolism and Biological Functions: Narrative Review" Metabolites 15, no. 7: 436. https://doi.org/10.3390/metabo15070436
APA StyleKowalówka, M., Górna, I., Karaźniewicz-Łada, M., Kusyk, D., Przysławski, J., & Drzymała-Czyż, S. (2025). Nutri-Epigenetic Regulation of Vitamin D—Impact on Metabolism and Biological Functions: Narrative Review. Metabolites, 15(7), 436. https://doi.org/10.3390/metabo15070436