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Review

Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response

1
Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
2
Section of Bioanalytical Chemistry, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK
3
National Phenome Centre, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Brent Warren Winston, Angela Rogers, Kathleen A. Stringer and Chel Hee Lee
Metabolites 2022, 12(5), 376; https://doi.org/10.3390/metabo12050376
Received: 12 March 2022 / Revised: 1 April 2022 / Accepted: 12 April 2022 / Published: 21 April 2022
(This article belongs to the Special Issue Using Metabolomics to Subphenotype Disease and Therapeutic Response)
Infections are common and need minimal treatment; however, occasionally, due to inappropriate immune response, they can develop into a life-threatening condition known as sepsis. Sepsis is a global concern with high morbidity and mortality. There has been little advancement in the treatment of sepsis, outside of antibiotics and supportive measures. Some of the difficulty in identifying novel therapies is the heterogeneity of the condition. Metabolic phenotyping has great potential for gaining understanding of this heterogeneity and how the metabolic fingerprints of patients with sepsis differ based on survival, organ dysfunction, disease severity, type of infection, treatment or causative organism. Moreover, metabolomics offers potential for patient stratification as metabolic profiles obtained from analytical platforms can reflect human individuality and phenotypic variation. This article reviews the most relevant metabolomic studies in sepsis and aims to provide an overview of the metabolic derangements in sepsis and how metabolic phenotyping has been used to identify sub-groups of patients with this condition. Finally, we consider the new avenues that metabolomics could open, exploring novel phenotypes and untangling the heterogeneity of sepsis, by looking at advances made in the field with other -omics technologies. View Full-Text
Keywords: sepsis; metabolomics; sub-phenotyping; organ dysfunction; patient stratification; NMR; LC-MS sepsis; metabolomics; sub-phenotyping; organ dysfunction; patient stratification; NMR; LC-MS
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MDPI and ACS Style

Hussain, H.; Vutipongsatorn, K.; Jiménez, B.; Antcliffe, D.B. Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response. Metabolites 2022, 12, 376. https://doi.org/10.3390/metabo12050376

AMA Style

Hussain H, Vutipongsatorn K, Jiménez B, Antcliffe DB. Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response. Metabolites. 2022; 12(5):376. https://doi.org/10.3390/metabo12050376

Chicago/Turabian Style

Hussain, Humma, Kritchai Vutipongsatorn, Beatriz Jiménez, and David B. Antcliffe. 2022. "Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response" Metabolites 12, no. 5: 376. https://doi.org/10.3390/metabo12050376

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