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Article

Evaluation of the Links between Lamb Feed Efficiency and Rumen and Plasma Metabolomic Data

1
GenPhySE, Université de Toulouse, INRAE, ENVT, F-31326 Castanet-Tolosan, France
2
Ecole Nationale Vétérinaire de Toulouse, F-31300 Toulouse, France
3
INRAE, Experimental Unit P3R, F-18390 Osmoy, France
*
Author to whom correspondence should be addressed.
Academic Editor: Cholsoon Jang
Metabolites 2022, 12(4), 304; https://doi.org/10.3390/metabo12040304
Received: 4 February 2022 / Revised: 23 March 2022 / Accepted: 24 March 2022 / Published: 29 March 2022
(This article belongs to the Section Nutrition and Metabolism)
Feed efficiency is one of the keystones that could help make animal production less costly and more environmentally friendly. Residual feed intake (RFI) is a widely used criterion to measure feed efficiency by regressing intake on the main energy sinks. We investigated rumen and plasma metabolomic data on Romane male lambs that had been genetically selected for either feed efficiency (line rfi−) or inefficiency (line rfi+). These investigations were conducted both during the growth phase under a 100% concentrate diet and later on under a mixed diet to identify differential metabolite expression and to link it to biological phenomena that could explain differences in feed efficiency. Nuclear magnetic resonance (NMR) data were analyzed using partial least squares discriminant analysis (PLS-DA), and correlations between metabolites’ relative concentrations were estimated to identify relationships between them. High levels of plasma citrate and malate were associated with genetically efficient animals, while high levels of amino acids such as L-threonine, L-serine, and L-leucine as well as beta-hydroxyisovalerate were associated with genetically inefficient animals under both diets. The two divergent lines could not be discriminated using rumen metabolites. Based on phenotypic residual feed intake (RFI), efficient and inefficient animals were discriminated using plasma metabolites determined under a 100% concentrate diet, but no discrimination was observed with plasma metabolites under a mixed diet or with rumen metabolites regardless of diet. Plasma amino acids, citrate, and malate were the most discriminant metabolites, suggesting that protein turnover and the mitochondrial production of energy could be the main phenomena that differ between efficient and inefficient Romane lambs. View Full-Text
Keywords: residual feed intake; NMR; plasma; rumen; multivariate analysis residual feed intake; NMR; plasma; rumen; multivariate analysis
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MDPI and ACS Style

Touitou, F.; Tortereau, F.; Bret, L.; Marty-Gasset, N.; Marcon, D.; Meynadier, A. Evaluation of the Links between Lamb Feed Efficiency and Rumen and Plasma Metabolomic Data. Metabolites 2022, 12, 304. https://doi.org/10.3390/metabo12040304

AMA Style

Touitou F, Tortereau F, Bret L, Marty-Gasset N, Marcon D, Meynadier A. Evaluation of the Links between Lamb Feed Efficiency and Rumen and Plasma Metabolomic Data. Metabolites. 2022; 12(4):304. https://doi.org/10.3390/metabo12040304

Chicago/Turabian Style

Touitou, Florian, Flavie Tortereau, Lydie Bret, Nathalie Marty-Gasset, Didier Marcon, and Annabelle Meynadier. 2022. "Evaluation of the Links between Lamb Feed Efficiency and Rumen and Plasma Metabolomic Data" Metabolites 12, no. 4: 304. https://doi.org/10.3390/metabo12040304

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