Dental Diseases Increase Risk of Aortic Arch Calcification Independent of Renal Dysfunction in Older Adults: Shenzhen Community Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Data Collection
2.2. Demographic Characteristics and Baseline Diameters Measurement
2.3. Radiographic Evaluation
2.4. Dental Examination
2.5. Statistical Analysis
3. Results
3.1. Clinical Characteristics of Participants with or without AoAC
3.2. Association Rule Analysis Suggests a Strong Association between Dental Diseases and AoAC
3.3. Dental Diseases Were Independent Risk Factors for AoAC
3.4. Dental Diseases Increase the Risk of AoAC Progression Independent of Renal Dysfunction
4. Discussion
5. Conclusions
6. Limitations
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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All Subjects | Non-AoAC | AoAC | p-Value | |
---|---|---|---|---|
Number | 9463 | 1432 | 8031 | |
Demographics | ||||
Age, years | 70.76 ± 5.74 | 69.59 ± 4.87 | 70.97 ± 5.86 | <0.001 |
Female, n (%) | 5441 (57.50) | 717 (50.07) | 4724 (58.82) | <0.001 |
SBP, mmHg | 136.39 ± 17.47 | 134.90 ± 17.22 | 136.65 ± 17.50 | <0.001 |
DBP, mmHg | 77.36 ± 10.34 | 77.22 ± 10.39 | 77.39 ± 10.33 | 0.555 |
BMI, kg/m2 | 24.02 ± 3.13 | 24.07 ± 3.03 | 24.01 ± 3.15 | 0.497 |
Medical history | ||||
CHD, n (%) | 906 (9.57) | 136 (9.50) | 770 (9.59) | 0.953 |
Hypertension, n (%) | 7648 (80.82) | 1082 (75.56) | 6566 (81.76) | <0.001 |
Diabetes Mellitus, n (%) | 1963 (20.74) | 287 (20.04) | 1676 (20.87) | 0.499 |
Hyperlipidemia, n (%) | 3627 (38.33) | 470 (32.82) | 3157 (39.31) | <0.001 |
Dental health | ||||
Tooth loss, n (%) | 7278 (76.91) | 1044 (72.91) | 6234 (77.62) | <0.001 |
Tooth decay, n (%) | 1160 (12.26) | 163 (11.38) | 997 (12.41) | 0.292 |
Tooth loss or decay, n (%) | 7550 (79.78) | 1077 (75.21) | 6473 (80.60) | <0.001 |
Hematology and biochemical test | ||||
WBC, 109/L | 6.20 (5.20, 7.20) | 6.20 (5.39, 7.30) | 6.12 (5.20, 7.20) | 0.063 |
HGB, g/L | 134.43 ± 13.51 | 136.04 ± 13.41 | 134.14 ± 13.51 | <0.001 |
PLT, 109/L | 208.70 ± 50.04 | 209.98 ± 50.10 | 208.47 ± 50.03 | 0.294 |
TG, mmol/L | 1.28 (0.94, 1.78) | 1.29 (0.94, 1.78) | 1.28 (0.94, 1.78) | 0.814 |
TC, mmol/L | 5.03 (4.34, 5.75) | 4.98 (4.32, 5.67) | 5.03 (4.34, 5.76) | 0.075 |
LDL-C, mmol/L | 2.90 (2.28, 3.55) | 2.88 (2.32, 3.49) | 2.91 (2.27, 3.56) | 0.703 |
HDL-C, mmol/L | 1.40 (1.19, 1.67) | 1.38 (1.15, 1.61) | 1.41 (1.20, 1.68) | <0.001 |
FPG, mmol/L | 5.46 (4.94, 6.24) | 5.42 (4.86, 6.21) | 5.46 (4.96, 6.24) | 0.022 |
eGFR, mL/min/1.73 m2 | 72.95 (64.11, 86.58) | 70.21 (63.55, 77.78) | 73.63 (64.36, 88.18) | <0.001 |
Lifestyle | ||||
Smoking, n (%) | 1526 (16.13) | 243 (16.97) | 1283 (15.98) | 0.367 |
Drinking, n (%) | 2092 (22.11) | 337 (23.53) | 1755 (21.85) | 0.168 |
Physical activity hours/week, n (%) | 0.122 | |||
<3 h | 2256 (23.84) | 330 (23.04) | 1926 (23.98) | |
3–10 h | 6101 (64.47) | 912 (63.69) | 5189 (64.61) | |
>10 h | 1106 (11.69) | 190 (13.27) | 916 (11.41) |
Variables | OR | 95% CI | p Value |
Unadjusted | |||
Tooth loss | 1.289 | 1.135–1.465 | <0.001 |
Tooth decay | 1.103 | 0.925–1.316 | 0.273 |
Tooth loss or decay | 1.369 | 1.200–1.563 | <0.001 |
Model 1 | |||
Tooth loss | 1.172 | 1.028–1.336 | 0.018 |
Tooth decay | 1.113 | 0.932–1.329 | 0.236 |
Tooth loss or decay | 1.248 | 1.090–1.428 | 0.001 |
Model 2 | |||
Tooth loss | 1.154 | 1.012–1.317 | 0.032 |
Tooth decay | 1.091 | 0.913–1.303 | 0.337 |
Tooth loss or decay | 1.223 | 1.068–1.401 | 0.004 |
Model 3 | |||
Tooth loss | 1.110 | 0.971–1.268 | 0.125 |
Tooth decay | 1.015 | 0.848–1.216 | 0.868 |
Tooth loss or decay | 1.158 | 1.010–1.329 | 0.036 |
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Yin, L.; Zhang, Z.; Xie, C.; Luo, D.; He, W.; Huang, S.; Huang, H. Dental Diseases Increase Risk of Aortic Arch Calcification Independent of Renal Dysfunction in Older Adults: Shenzhen Community Cohort Study. Metabolites 2022, 12, 1258. https://doi.org/10.3390/metabo12121258
Yin L, Zhang Z, Xie C, Luo D, He W, Huang S, Huang H. Dental Diseases Increase Risk of Aortic Arch Calcification Independent of Renal Dysfunction in Older Adults: Shenzhen Community Cohort Study. Metabolites. 2022; 12(12):1258. https://doi.org/10.3390/metabo12121258
Chicago/Turabian StyleYin, Li, Zhengzhipeng Zhang, Changming Xie, Dongling Luo, Wanbing He, Suli Huang, and Hui Huang. 2022. "Dental Diseases Increase Risk of Aortic Arch Calcification Independent of Renal Dysfunction in Older Adults: Shenzhen Community Cohort Study" Metabolites 12, no. 12: 1258. https://doi.org/10.3390/metabo12121258
APA StyleYin, L., Zhang, Z., Xie, C., Luo, D., He, W., Huang, S., & Huang, H. (2022). Dental Diseases Increase Risk of Aortic Arch Calcification Independent of Renal Dysfunction in Older Adults: Shenzhen Community Cohort Study. Metabolites, 12(12), 1258. https://doi.org/10.3390/metabo12121258