Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Patients
2.3. Control Groups
2.4. Clinical and Body Composition Parameters
2.5. Laboratory Measurements
2.6. Euglycemic Hyperinsulinemic Clamp Study
2.7. Statistical Analysis
3. Results
3.1. Clinical Characteristics of Adult Patients with GHD without GH Replacement
3.2. Comparative Analysis between COGHD and AOGHD Patients
3.3. Comparative Analysis between COGHD Patients and Respective Control Group
3.4. Comparative Analysis between AOGHD Patients and Respective Control Group
3.5. Correlation between IS and PFM in Adult Patients with GHD according to the Stage of the Disease Onset and Control Group
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Patients (n = 17) | Sex | Age (years) | BMI (kg/m2) | Treatment | Etiology Hp | IGF-1 (ng/mL) | F-Gly (mg/dL) | PFFM (%) | PFM (%) | M/FFM (mg/kg/min) |
---|---|---|---|---|---|---|---|---|---|---|
Childhood-onset GHD | ||||||||||
Pt-1 | M | 40 | 18.80 | P-L-T | CPH | 34.44 | 69.7 | 75.9 | 24.1 | 10.5 |
Pt-2 | M | 32 | 24.61 | P-L-T-D | CPGP | 52.6 | 77.5 | 77.5 | 22.5 | 8.8 |
Pt-3 | M | 23 | 17.78 | P-L-T | CPH | 40.1 | 79.5 | 62.2 | 37.8 | 10.6 |
Pt-4 | M | 24 | 17.70 | P-L-T-D | CPGP | 18.39 | 71.9 | 65.4 | 34.6 | 13.7 |
Pt-5 | M | 25 | 20.28 | P-L-T | CPH | 36.33 | 77.5 | 79.6 | 20.4 | 12.9 |
Pt-6 | M | 22 | 35.10 | P-L-T-D | CPGP | 69.65 | 81.5 | 68.5 | 31.5 | 3.0 |
Pt-7 | F | 24 | 21.52 | P-L-Es/Pg | CPH | 25.4 | 75.1 | 70.3 | 29.7 | 12.5 |
Pt-8 | F | 22 | 23.14 | P-L-Es/Pg | CPH | 36.69 | 70.7 | 70.1 | 29.9 | 4.8 |
Pt-9 | F | 22 | 19.80 | P-L-Es/Pg | CPH | 71.68 | 85.0 | 67.8 | 32.2 | 7.8 |
Pt-10 | M | 22 | 25.30 | P-L-T | CPH | 70.1 | 77.4 | 72.8 | 27.2 | 11.0 |
Adulthood-onset GHD | ||||||||||
Pt-1 | F | 32 | 22.06 | P-L-Es/Pg | ES | 22.67 | 70.8 | 65.4 | 34.6 | 6.0 |
Pt-2 | M | 50 | 31.92 | P-L-T | NFPM | 18.8 | 84.6 | 65.7 | 34.3 | 4.9 |
Pt-3 | F | 56 | 41.21 | P-L | SHS | 47.64 | 92.5 | 56.6 | 43.4 | 2.8 |
Pt-4 | M | 50 | 31.50 | P-L-T | NFPM | 31 | 71.2 | 76.2 | 23.8 | 6.8 |
Pt-5 | M | 41 | 46.00 | P-L-T-D | NFPM | 30.11 | 92.5 | 63.5 | 36.5 | 2.9 |
Pt-6 | F | 42 | 21.90 | P-L-Es/Pg | ES | 31.5 | 74.7 | 66.3 | 33.7 | 4.5 |
Pt-7 | F | 38 | 35.2 | P-L-Es/Pg | SHS | 25.2 | 78.1 | 58.1 | 41.9 | 2.9 |
Variable | COGHD (n = 10) | Control-COGHD (n = 20) | AOGHD (n = 7) | Control-AOGHD (n = 14) |
---|---|---|---|---|
Sex (female) | 3 (33.3%) | 6 (33.3%) | 4 (57.1%) | 8 (57.1%) |
Age (years) | 28.3 ± 9.6 24.0 (22.0–50.0) a | 28.5 ± 8.9 25·5 (20.0–50.0) | 40.3 ± 10.9 41·0 (23.0–56.0) | 39.0 ± 9.8 39·5 (23.0–54.0) |
BMI (kg/m2) | 22.4 ± 5.2 20.9 (17.7–35.1) a | 23.4 ± 3.7 23·1 (17.9–34.9) | 32.8 ± 9.0 31.9 (21.9–46.0) | 33.5 ± 8.6 31.5 (22.6–48.6) |
F-Gly (mg/dL) | 76.6 ± 5.1 77.5 (69.7–85.0) b | 86.5 ± 5.9 86.3 (73.3–97.4) | 80.6 ± 9.3 78.1 (70.8–92.5) | 85.3 ± 7.4 87.9 (73.2–94.6) |
IGF-1 (ng/mL) | 42.8 ± 18.4 36.7 (18.4–71.7) b | 195.7 ± 56.6 212.7 (102.4–286.1) | 31.1 ± 9.4 30.6 (18.8–47.6) c | 133.7 ± 70.7 111.3 (75.4–261.7) |
PFFM (%) | 71.0 ± 5.5 70.2 (62.2–79.6) b | 80.8 ± 7.8 81.6 (63.9–97.0) | 64.5 ± 6.4 65.4 (56.6–76.2) | 65.6 ± 8.6 67.8 (47.2–77.7) |
PFM (%) | 29.0 ± 5.5 29.8 (20.4–37.8) b | 19.2 ± 7.8 18.4 (3.0–36.1) | 35.5 ± 6.4 34.6 (23.8–43.4) | 34.4 ± 8.6 32.3 (22.3–52.8) |
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Garmes, H.M.; Castillo, A.R.; Monte Alegre, S.; de Souza, A.L.; Atala, Y.B.; Zantut-Wittmann, D.E. Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity. Metabolites 2022, 12, 1251. https://doi.org/10.3390/metabo12121251
Garmes HM, Castillo AR, Monte Alegre S, de Souza AL, Atala YB, Zantut-Wittmann DE. Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity. Metabolites. 2022; 12(12):1251. https://doi.org/10.3390/metabo12121251
Chicago/Turabian StyleGarmes, Heraldo Mendes, Alejandro Rosell Castillo, Sarah Monte Alegre, Aglecio Luiz de Souza, Yeelen Ballesteros Atala, and Denise Engelbrecht Zantut-Wittmann. 2022. "Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity" Metabolites 12, no. 12: 1251. https://doi.org/10.3390/metabo12121251