R Shiny App for the Automated Deconvolution of NMR Spectra to Quantify the Solid-State Forms of Pharmaceutical Mixtures
Abstract
:1. Introduction
2. Materials and Methods
2.1. Algorithm
2.2. R Shiny Application
- “no optimisation, apply the fixed processing values”: No optimisation is performed; the manually specified values in the input fields corresponding to (note that ) are directly applied to process (according to Equation (1)) and visualise the spectra.
- “optimise only proportion”: The same workflow as above, except that now the parameter is estimated, offering a compromise between fully manual and fully automated processing and deconvolution.
- “optimise proportion and other processing parameters”: This entails the fully automated optimisation of the five model parameters.
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
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Prostko, P.; Pikkemaat, J.; Selter, P.; Lukaschek, M.; Wechselberger, R.; Khamiakova, T.; Valkenborg, D. R Shiny App for the Automated Deconvolution of NMR Spectra to Quantify the Solid-State Forms of Pharmaceutical Mixtures. Metabolites 2022, 12, 1248. https://doi.org/10.3390/metabo12121248
Prostko P, Pikkemaat J, Selter P, Lukaschek M, Wechselberger R, Khamiakova T, Valkenborg D. R Shiny App for the Automated Deconvolution of NMR Spectra to Quantify the Solid-State Forms of Pharmaceutical Mixtures. Metabolites. 2022; 12(12):1248. https://doi.org/10.3390/metabo12121248
Chicago/Turabian StyleProstko, Piotr, Jeroen Pikkemaat, Philipp Selter, Michail Lukaschek, Rainer Wechselberger, Tatsiana Khamiakova, and Dirk Valkenborg. 2022. "R Shiny App for the Automated Deconvolution of NMR Spectra to Quantify the Solid-State Forms of Pharmaceutical Mixtures" Metabolites 12, no. 12: 1248. https://doi.org/10.3390/metabo12121248