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Volume 12
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Article

Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites

by
Jiahui Zheng
1,2,
Huan Li
1,2,
Pei Zhang
3,
Shijun Yue
1,4,
Bingtao Zhai
1,2,
Junbo Zou
1,2,
Jiangxue Cheng
1,2,
Chongbo Zhao
1,2,
Dongyan Guo
1,2,* and
Jing Wang
1,2,*
1
State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xi’an 712046, China
2
Shaanxi Key Laboratory of Traditional Chinese Medicine Foundation and New Drug Research, Shaanxi University of Chinese Medicine, Xi’an 712046, China
3
State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China
4
Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi’an 712046, China
*
Authors to whom correspondence should be addressed.
Metabolites 2022, 12(10), 956; https://doi.org/10.3390/metabo12100956
Submission received: 5 September 2022 / Revised: 28 September 2022 / Accepted: 5 October 2022 / Published: 8 October 2022
(This article belongs to the Special Issue Gut Microbiome-Associated Nutrition and Metabolism in Livestock Production)
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Abstract

Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the gastrointestinal tract. Recent studies demonstrate that the phenolic tannin paeonol (Pae) attenuates UC in mouse models by downregulating inflammatory factors. However, its molecular mechanism for UC treatment has not been explored from the perspective of the gut microbiota and metabolomics. In this study, we investigated the effects of Pae on colonic inflammation, intestinal microbiota and fecal metabolites in 3% dextran sodium sulfate (DSS) induced BALB/c UC mice. Pae significantly improved the clinical index, relieved colonic damage, reduced cytokine levels, and restored the integrity of the intestinal epithelial barrier in UC mice. In addition, Pae increased the abundance of gut microbiota, partially reversed the disturbance of intestinal biota composition, including Lactobacillus and Bacteroides, and regulated metabolite levels, such as bile acid (BA) and short-chain fatty acid (SCFA). In conclusion, our study provides new insight on Pae remission of UC.
Keywords: paeonol; ulcerative colitis; dextran sodium sulfate; gut microbiota; metabolomics paeonol; ulcerative colitis; dextran sodium sulfate; gut microbiota; metabolomics
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MDPI and ACS Style

Zheng, J.; Li, H.; Zhang, P.; Yue, S.; Zhai, B.; Zou, J.; Cheng, J.; Zhao, C.; Guo, D.; Wang, J. Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites. Metabolites 2022, 12, 956. https://doi.org/10.3390/metabo12100956

AMA Style

Zheng J, Li H, Zhang P, Yue S, Zhai B, Zou J, Cheng J, Zhao C, Guo D, Wang J. Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites. Metabolites. 2022; 12(10):956. https://doi.org/10.3390/metabo12100956

Chicago/Turabian Style

Zheng, Jiahui, Huan Li, Pei Zhang, Shijun Yue, Bingtao Zhai, Junbo Zou, Jiangxue Cheng, Chongbo Zhao, Dongyan Guo, and Jing Wang. 2022. "Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites" Metabolites 12, no. 10: 956. https://doi.org/10.3390/metabo12100956

APA Style

Zheng, J., Li, H., Zhang, P., Yue, S., Zhai, B., Zou, J., Cheng, J., Zhao, C., Guo, D., & Wang, J. (2022). Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites. Metabolites, 12(10), 956. https://doi.org/10.3390/metabo12100956

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