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Metabolites
Volume 11
Issue 8
10.3390/metabo11080527
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Article

An Oenothera biennis Cell Cultures Extract Endowed with Skin Anti-Ageing Activity Improves Cell Mechanical Properties

by
Sara Ceccacci
1,2,
Adriana De Lucia
3,
Annalisa Tito
3,
Assunta Tortora
3,
Danila Falanga
3,
Stefania Arciello
3,
Giovanni Ausanio
4,
Chiara Di Cicco
5,
Maria Chiara Monti
1,* and
Fabio Apone
3,6
1
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
2
PhD Program in Drug Discovery and Development, Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
3
Arterra Bioscience SpA, 80142 Naples, Italy
4
CNR-SPIN Department of Physics, University of Naples “Federico II”, 80125 Naples, Italy
5
Department of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, Italy
6
Vitalab Srl, 80142 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Mario Juan Simirgiotis Aguero and Ute Roessner
Metabolites 2021, 11(8), 527; https://doi.org/10.3390/metabo11080527
Received: 27 July 2021 / Revised: 4 August 2021 / Accepted: 4 August 2021 / Published: 9 August 2021
(This article belongs to the Special Issue Plant and Derived Natural Product Metabolomics Volume 2)
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Abstract

Skin aging is a very well-known process setting a gradual worsening of skin mechanical features due to a decline in the production of the extra-cellular matrix machinery and to a concurrent change in the contraction process. To slow this progression, it is crucial to induce the expression of several proteins able to promote elastic fibers formation and tissue repair. Here, the Oenothera biennis cell culture aqueous extract has been investigated from a chemical point of view and then it was tested in vitro, in cell, and in ex vivo experiments as adjuvant in counteracting skin aging. Accordingly, it has been shown that the Oenothera biennis extract was able, by increasing MYLK gene expression, to promote matrix collagen contraction, actin polymerization, and the production of essential ECM proteins. View Full-Text
Keywords: metabolomics; molecular networks; hydrophilic extract of Oenothera biennis cell cultures; matrix collagen contraction; skin aging metabolomics; molecular networks; hydrophilic extract of Oenothera biennis cell cultures; matrix collagen contraction; skin aging
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MDPI and ACS Style

Ceccacci, S.; De Lucia, A.; Tito, A.; Tortora, A.; Falanga, D.; Arciello, S.; Ausanio, G.; Di Cicco, C.; Monti, M.C.; Apone, F. An Oenothera biennis Cell Cultures Extract Endowed with Skin Anti-Ageing Activity Improves Cell Mechanical Properties. Metabolites 2021, 11, 527. https://doi.org/10.3390/metabo11080527

AMA Style

Ceccacci S, De Lucia A, Tito A, Tortora A, Falanga D, Arciello S, Ausanio G, Di Cicco C, Monti MC, Apone F. An Oenothera biennis Cell Cultures Extract Endowed with Skin Anti-Ageing Activity Improves Cell Mechanical Properties. Metabolites. 2021; 11(8):527. https://doi.org/10.3390/metabo11080527

Chicago/Turabian Style

Ceccacci, Sara, Adriana De Lucia, Annalisa Tito, Assunta Tortora, Danila Falanga, Stefania Arciello, Giovanni Ausanio, Chiara Di Cicco, Maria Chiara Monti, and Fabio Apone. 2021. "An Oenothera biennis Cell Cultures Extract Endowed with Skin Anti-Ageing Activity Improves Cell Mechanical Properties" Metabolites 11, no. 8: 527. https://doi.org/10.3390/metabo11080527

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