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Article

Serum Metabolites Responding in a Dose-Dependent Manner to the Intake of a High-Fat Meal in Normal Weight Healthy Men Are Associated with Obesity

1
Food Microbial Systems Research Division, Agroscope, Schwarzenburgstrasse 161, 3003 Berne, Switzerland
2
Instrumat AG, Ch. de la Rueyre 116-118, 1020 Renens, Switzerland
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Nisco ApS, 2630 Taastrup, Denmark
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School of Agricultural, Forest and Food Sciences HAFL, Bern University, 3052 Zollikofen, Switzerland
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Department of Visceral Surgery and Medicine, University Hospital of Berne, 3010 Berne, Switzerland
6
Halteneggweg 3, 3145 Niederscherli, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editors: Isabel Moreno-Indias and Carolina Gutiérrez-Repiso
Metabolites 2021, 11(6), 392; https://doi.org/10.3390/metabo11060392
Received: 27 May 2021 / Revised: 11 June 2021 / Accepted: 15 June 2021 / Published: 16 June 2021
(This article belongs to the Special Issue Metabolic Health and Weight II)
Although the composition of the human blood metabolome is influenced both by the health status of the organism and its dietary behavior, the interaction between these two factors has been poorly characterized. This study makes use of a previously published randomized controlled crossover acute intervention to investigate whether the blood metabolome of 15 healthy normal weight (NW) and 17 obese (OB) men having ingested three doses (500, 1000, 1500 kcal) of a high-fat (HF) meal can be used to identify metabolites differentiating these two groups. Among the 1024 features showing a postprandial response, measured between 0 h and 6 h, in the NW group, 135 were dose-dependent. Among these 135 features, 52 had fasting values that were significantly different between NW and OB men, and, strikingly, they were all significantly higher in OB men. A subset of the 52 features was identified as amino acids (e.g., branched-chain amino acids) and amino acid derivatives. As the fasting concentration of most of these metabolites has already been associated with metabolic dysfunction, we propose that challenging normal weight healthy subjects with increasing caloric doses of test meals might allow for the identification of new fasting markers associated with obesity. View Full-Text
Keywords: obesity; postprandial challenge; caloric-dose response; serum metabolome obesity; postprandial challenge; caloric-dose response; serum metabolome
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MDPI and ACS Style

Bütikofer, U.; Burnand, D.; Portmann, R.; Blaser, C.; Schwander, F.; Kopf-Bolanz, K.A.; Laederach, K.; Badertscher, R.; Walther, B.; Vergères, G. Serum Metabolites Responding in a Dose-Dependent Manner to the Intake of a High-Fat Meal in Normal Weight Healthy Men Are Associated with Obesity. Metabolites 2021, 11, 392. https://doi.org/10.3390/metabo11060392

AMA Style

Bütikofer U, Burnand D, Portmann R, Blaser C, Schwander F, Kopf-Bolanz KA, Laederach K, Badertscher R, Walther B, Vergères G. Serum Metabolites Responding in a Dose-Dependent Manner to the Intake of a High-Fat Meal in Normal Weight Healthy Men Are Associated with Obesity. Metabolites. 2021; 11(6):392. https://doi.org/10.3390/metabo11060392

Chicago/Turabian Style

Bütikofer, Ueli, David Burnand, Reto Portmann, Carola Blaser, Flurina Schwander, Katrin A. Kopf-Bolanz, Kurt Laederach, René Badertscher, Barbara Walther, and Guy Vergères. 2021. "Serum Metabolites Responding in a Dose-Dependent Manner to the Intake of a High-Fat Meal in Normal Weight Healthy Men Are Associated with Obesity" Metabolites 11, no. 6: 392. https://doi.org/10.3390/metabo11060392

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