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Article

Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors

1
Laboratory of Neuroendocrinology, Department of Neuroscience, University of Torino, 10126 Torino, Italy
2
Neuroscience Institute Cavalieri-Ottolenghi (NICO), 10043 Orbassano, Italy
3
Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy
4
Clinical Chemistry Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
*
Author to whom correspondence should be addressed.
Equally contributed and should be considered as joint first authors.
Academic Editor: Amedeo Lonardo
Metabolites 2021, 11(6), 368; https://doi.org/10.3390/metabo11060368
Received: 24 March 2021 / Revised: 4 June 2021 / Accepted: 6 June 2021 / Published: 9 June 2021
(This article belongs to the Special Issue Neuroendocrine Control of Energy Metabolism)
In the arcuate nucleus, neuropeptide Y (NPY) neurons, increase food intake and decrease energy expenditure, and control the activity of pro-opiomelanocortin (POMC) neurons, that decrease food intake and increase energy expenditure. Both systems project to other hypothalamic nuclei such as the paraventricular and dorsomedial hypothalamic nuclei. Endocrine disrupting chemicals (EDCs) are environmental contaminants that alter the endocrine system causing adverse health effects in an intact organism or its progeny. We investigated the effects of long-term exposure to some EDCs on the hypothalamic NPY and POMC systems of adult male mice that had been previously demonstrated to be a target of some of these EDCs after short-term exposure. Animals were chronically fed for four months with a phytoestrogen-free diet containing two different concentrations of bisphenol A, diethylstilbestrol, tributyltin, or E2. At the end, brains were processed for NPY and POMC immunohistochemistry and quantitatively analyzed. In the arcuate and dorsomedial nuclei, both NPY and POMC immunoreactivity showed a statistically significant decrease. In the paraventricular nucleus, only the NPY system was affected, while the POMC system was not affected. Finally, in the VMH the NPY system was affected whereas no POMC immunoreactive material was observed. These results indicate that adult exposure to different EDCs may alter the hypothalamic circuits that control food intake and energy metabolism. View Full-Text
Keywords: endocrine disrupting chemicals; bisphenol A; diethylstilbestrol; tributyltin; neuropeptide Y; pro-opiomelanocortin endocrine disrupting chemicals; bisphenol A; diethylstilbestrol; tributyltin; neuropeptide Y; pro-opiomelanocortin
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MDPI and ACS Style

Marraudino, M.; Bo, E.; Carlini, E.; Farinetti, A.; Ponti, G.; Zanella, I.; Di Lorenzo, D.; Panzica, G.C.; Gotti, S. Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors. Metabolites 2021, 11, 368. https://doi.org/10.3390/metabo11060368

AMA Style

Marraudino M, Bo E, Carlini E, Farinetti A, Ponti G, Zanella I, Di Lorenzo D, Panzica GC, Gotti S. Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors. Metabolites. 2021; 11(6):368. https://doi.org/10.3390/metabo11060368

Chicago/Turabian Style

Marraudino, Marilena, Elisabetta Bo, Elisabetta Carlini, Alice Farinetti, Giovanna Ponti, Isabella Zanella, Diego Di Lorenzo, Gian C. Panzica, and Stefano Gotti. 2021. "Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors" Metabolites 11, no. 6: 368. https://doi.org/10.3390/metabo11060368

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