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Article

Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity

1
Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili (URV), 43201 Reus, Spain
2
Institute of Health Pere Virgili—IISPV, University Hospital Sant Joan, 43201 Reus, Spain
3
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
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Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Hospitalet de Llobregat, 08908 Barcelona, Spain
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Section for Obesity Research, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark
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Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool L69 3GL, UK
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Appetite Control & Energy Balance Research Group, School of Psychology, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Thusitha W. Rupasinghe
Metabolites 2021, 11(5), 317; https://doi.org/10.3390/metabo11050317
Received: 17 April 2021 / Revised: 5 May 2021 / Accepted: 12 May 2021 / Published: 13 May 2021
(This article belongs to the Section Metabolomic Profiling Technology)
The interplay between fat mass and lean mass within human metabolism is not completely understood. We aimed to identify specific circulating metabolomic profiles associated with these body composition compartments. Cross-sectional analyses were conducted over 236 adults with overweight/obesity from the Satiety Innovation (SATIN) study. Body composition was assessed by dual-energy X-ray absorptiometry. A targeted multiplatform metabolite profiling approach was applied. Associations between 168 circulating metabolites and the body composition measures were assessed using elastic net regression analyses. The accuracy of the multimetabolite weighted models was evaluated using a 10-fold cross-validation approach and the Pearson’s correlation coefficients between metabolomic profiles and body compartments were estimated. Two different profiles including 86 and 65 metabolites were selected for % body fat and lean mass. These metabolites mainly consisted of lipids (sphingomyelins, phosphatidylcholines, lysophosphatidylcholines), acylcarnitines, and amino acids. Several metabolites overlapped between these body composition measures but none of them towards the same direction. The Pearson correlation coefficients between the metabolomic profiles and % body fat or lean mass were 0.80 and 0.79, respectively. Our findings suggest alterations in lipid metabolism, fatty acid oxidation, and protein degradation with increased adiposity and decreased lean body mass. These findings could help us to better understand the interplay between body composition compartments with human metabolic processes. View Full-Text
Keywords: metabolomics; body composition; fat mass; lean mass; satiety innovation (SATIN) metabolomics; body composition; fat mass; lean mass; satiety innovation (SATIN)
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MDPI and ACS Style

Papandreou, C.; García-Gavilán, J.; Camacho-Barcia, L.; Hansen, T.T.; Sjödin, A.; Harrold, J.A.; Halford, J.C.G.; Bulló, M. Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity. Metabolites 2021, 11, 317. https://doi.org/10.3390/metabo11050317

AMA Style

Papandreou C, García-Gavilán J, Camacho-Barcia L, Hansen TT, Sjödin A, Harrold JA, Halford JCG, Bulló M. Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity. Metabolites. 2021; 11(5):317. https://doi.org/10.3390/metabo11050317

Chicago/Turabian Style

Papandreou, Christopher, Jesús García-Gavilán, Lucía Camacho-Barcia, Thea T. Hansen, Anders Sjödin, Joanne A. Harrold, Jason C.G. Halford, and Mònica Bulló. 2021. "Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity" Metabolites 11, no. 5: 317. https://doi.org/10.3390/metabo11050317

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