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Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes

1
Clinic of Endocrinology and Diabetology, Children’s Memorial Health Institute, 04-730 Warsaw, Poland
2
Electromyography and Evoked Potential Laboratory, Children’s Memorial Health Institute, 04-730 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Amedeo Lonardo
Metabolites 2021, 11(11), 795; https://doi.org/10.3390/metabo11110795
Received: 29 September 2021 / Revised: 11 November 2021 / Accepted: 17 November 2021 / Published: 22 November 2021
(This article belongs to the Section Endocrinology and Clinical Metabolic Research)
Type 1 diabetes (T1D) in the child population is the third most common chronic disease. Diabetic peripheral neuropathy (DPN) is a very disabling and silently developing complication. This prospective, observational study enrolled 182 (93 girls) patients with T1D, aged 16.5–18 years. The aim of the study was to assess the correlation between factors of diabetes metabolic control, blood count, thyroid hormones, thyroid-stimulating hormone (TSH), level of cortisol, vitamin D3, metabolic factors, demographic data, and nerve conduction study (NCS) parameters. We revealed that in multivariate regression models for almost all NCS parameters, beside height and diabetes duration, significant factors were basal insulin dose per kilogram of weight (BID/kg), body mass index (BMI), and thyroid hormones. For conduction velocities of the motor nerves, mean HbA1c exists in models. In all models for all NCS parameters there exists at least one parameter of peripheral white blood cell counts (predominantly monocytes). There is a significant influence of thyroid hormones, peripheral blood white cells count, and BID per weight on parameters of NCS. It is essential to take care of the proper insulin dose per weight of patients and the adequate proportion of basal to prandial insulin. View Full-Text
Keywords: type 1 diabetes; neuropathy; children; thyroid hormones; white blood count; risk factors type 1 diabetes; neuropathy; children; thyroid hormones; white blood count; risk factors
MDPI and ACS Style

Wysocka-Mincewicz, M.; Baszyńska-Wilk, M.; Mazur, M.; Byczyńska, A.; Nowacka-Gotowiec, M. Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes. Metabolites 2021, 11, 795. https://doi.org/10.3390/metabo11110795

AMA Style

Wysocka-Mincewicz M, Baszyńska-Wilk M, Mazur M, Byczyńska A, Nowacka-Gotowiec M. Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes. Metabolites. 2021; 11(11):795. https://doi.org/10.3390/metabo11110795

Chicago/Turabian Style

Wysocka-Mincewicz, Marta, Marta Baszyńska-Wilk, Maria Mazur, Aleksandra Byczyńska, and Monika Nowacka-Gotowiec. 2021. "Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes" Metabolites 11, no. 11: 795. https://doi.org/10.3390/metabo11110795

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