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Review

An Integrative Approach to Assessing Diet–Cancer Relationships

by 1,2
1
Cancer Control Research, BC Cancer, 2-107 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada
2
School of Population and Public Health, University of British Columbia, 167-2206 East Mall, Vancouver, BC V6T 1Z3, Canada
Metabolites 2020, 10(4), 123; https://doi.org/10.3390/metabo10040123
Received: 21 January 2020 / Revised: 23 March 2020 / Accepted: 24 March 2020 / Published: 25 March 2020
(This article belongs to the Special Issue Integrative-Metabolomics in Epidemiological Studies)
The relationship between diet and cancer is often viewed with skepticism by the public and health professionals, despite a considerable body of evidence and general consistency in recommendations over the past decades. A systems biology approach which integrates ‘omics’ data including metabolomics, genetics, metagenomics, transcriptomics and proteomics holds promise for developing a better understanding of how diet affects cancer and for improving the assessment of diet through biomarker discovery thereby renewing confidence in diet–cancer links. This review discusses the application of multi-omics approaches to studies of diet and cancer. Considerations and challenges that need to be addressed to facilitate the investigation of diet–cancer relationships with multi-omic approaches are also discussed. View Full-Text
Keywords: metabolomics; multi-omic; epidemiology; systems biology; integration metabolomics; multi-omic; epidemiology; systems biology; integration
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MDPI and ACS Style

Murphy, R. An Integrative Approach to Assessing Diet–Cancer Relationships. Metabolites 2020, 10, 123. https://doi.org/10.3390/metabo10040123

AMA Style

Murphy R. An Integrative Approach to Assessing Diet–Cancer Relationships. Metabolites. 2020; 10(4):123. https://doi.org/10.3390/metabo10040123

Chicago/Turabian Style

Murphy, Rachel. 2020. "An Integrative Approach to Assessing Diet–Cancer Relationships" Metabolites 10, no. 4: 123. https://doi.org/10.3390/metabo10040123

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