Effectiveness of Platelet-Rich Plasma in the Treatment of Androgenic Alopecia Compared to Placebo and Topical Minoxidil: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. PICOS
2.2. Study Selection
3. Results and Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author | Number of Patients and Gender | Outcome Measure | Treatment Protocol | Evaluation of the Effect Compared to Control Group | Age Range (years) | TrichoScan Difference in Density (%) |
---|---|---|---|---|---|---|
Takikawa et al., 2011 [16] | 26 (16 men, 10 women) | Hair density, hair cross section, | 5 sessions with 2–3-week intervals | Positive | 28–59 | 1.9% (control) 13.4% (PRP) 15.8% (PRP/DP) |
Shapiro et al., 2020 [17] | 35 (18 men, 17 women) | Hair density | 3 monthly treatment sessions with evaluation after 3 months after the final treatment | No difference between study group and control group Positive effect compared to the baseline | 18–58 | 10.7% (control) 13.3% (PRP) |
Gentile et al., 2015 [18] | 20 (20 men) | Residual hair count and hair density based on computerized trichogram | 3 sessions with 30-day intervals, final evaluation after 2 years | Positive | 19–63 | 2.4% (control) 28.6% (PRP) |
Cervelli et al., 2014 [19] | 10 (10 men) | Hair density, anagen/telogen ratio | 3 sessions with evaluation after 14 weeks, 6 months and 12 months | Positive | 22–60 | −1.8% (control) 14.8% (PRP) |
Alves and Grimalt, 2016 [20] | 22 (11 men, 11 women) | Hair density, mean anagen hairs | 3 sessions with 30-day intervals | Positive | 21–62 | 1.3% (control) 7.7% (PRP) |
Gentile et al., 2018 [21] | 23 (18 men, 5 women) | Hair density | 3 sessions with 30-day intervals, final evaluation 3 months after the last injection | Positive | 21–70 | 1% (control) 31% (PRP) |
Dubin et al., 2020 [22] | 30 (30 women) | Hair density | 3 sessions, with 1-month intervals, and final evaluation after 6 months | Positive | 27–85 | −4.5% (control) 12.8% (PRP) |
Rodrigues et al., 2019 [23] | 26 (26 men) | Hair density | 4 sessions, with 15-day intervals and final evaluation 3 months after the last treatment | Positive | 18–50 | No accurate data available |
Siah et al., 2020 [24] | 10 (1 man, 9 women) | Hair density | 5 sessions, with 2-week intervals and final evaluation 2 months after the last intervention | Positive | 20–55 | 1% (control) 12.8% (PRP) |
Tawfik and Osman, 2018 [25] | 30 (30 women) | Hair density | 4 sessions, with 1-week intervals and final evaluation 6 months after the last treatment | Positive | 20–45 | 24% (control) 104.9% (PRP) |
Sultana and Paul, 2020 [26] | 54 (54 men) | Hair density | 3 sessions with 4 weeks intervals | Positive | 18–50 | 13.2% (minoxidil 5%) 24% (PRP) |
Pakhomova and Smirnova, 2020 [27] | 69 (69 men) | Hair density | 4 procedures with 1 month intervals | Positive | 18–53 | 15.8% (minoxidil 5%) 11.7% (PRP) 32% (PRP + minoxidil 5%) |
Singh et al., 2020 [28] | 80 (80 men) | Hair density, patient self-assessment, photographies | 3 sessions with 1 month intervals and final evaluation after 2 months | Positive | 18–60 | −1.2% (Control) 54.9% (PRP) 36.7% (Minoxidil 5%) 67.1% (PRP + minoxidil 5%) |
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Borowiecka, J.M.; Dalewski, B.; Pałka, Ł. Effectiveness of Platelet-Rich Plasma in the Treatment of Androgenic Alopecia Compared to Placebo and Topical Minoxidil: A Systematic Review. Sci. Pharm. 2023, 91, 4. https://doi.org/10.3390/scipharm91010004
Borowiecka JM, Dalewski B, Pałka Ł. Effectiveness of Platelet-Rich Plasma in the Treatment of Androgenic Alopecia Compared to Placebo and Topical Minoxidil: A Systematic Review. Scientia Pharmaceutica. 2023; 91(1):4. https://doi.org/10.3390/scipharm91010004
Chicago/Turabian StyleBorowiecka, Julia Maria, Bartosz Dalewski, and Łukasz Pałka. 2023. "Effectiveness of Platelet-Rich Plasma in the Treatment of Androgenic Alopecia Compared to Placebo and Topical Minoxidil: A Systematic Review" Scientia Pharmaceutica 91, no. 1: 4. https://doi.org/10.3390/scipharm91010004