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Article

Retinal Vessel Density Changes on Optical Coherence Tomography Angiography and Predictive Factors in Normal-Tension Glaucoma Treated with Topical Beta-Blocker

by 1,2,3,†, 3,4,†, 2,3 and 1,*
1
Department of Electro-Optical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan
2
Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan
3
College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
4
Department of Radiation Oncology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan
*
Author to whom correspondence should be addressed.
Yun-Hsuan Lin and Shih-Ming Huang contributed equally.
Academic Editors: Francisco Javier Otero-Espinar and Susi Burgalassi
Sci. Pharm. 2021, 89(3), 40; https://doi.org/10.3390/scipharm89030040
Received: 21 July 2021 / Revised: 20 August 2021 / Accepted: 23 August 2021 / Published: 25 August 2021
(1) Background: Topical antiglaucoma medications may alter the microcirculation in the optic nerve head. We aimed to evaluate the changes in retinal vessel density (VD) on optical coherence tomography angiography (OCTA) in patients with newly diagnosed normal-tension glaucoma (NTG) treated with a topical beta-blocker. (2) Methods: This study included 80 patients diagnosed with NTG not using systemic medication, who received topical carteolol treatment between December 2019 and November 2020. We studied the changes in the OCTA VD/signal strength index (SSI) after the 6-month treatment period and determined the predictive factors affecting the changes in VD/SSI. (3) Results: After the 6-month treatment period, the peripapillary VD increased in 40 patients but decreased in the other 40 patients. The univariate and multivariate analyses revealed that old age and hypertension were significant factors associated with a VD/SSI decrease after carteolol treatment. Moreover, high baseline peripapillary, superficial, and deep macular VDs were significantly associated with the VD decrease after carteolol treatment. (4) Conclusions: Carteolol treatment could increase or decrease the VD in patients with NTG. The baseline VD, age, and hypertension could affect these VD changes. Patients with NTG and higher baseline peripapillary or macular VD, older age, and hypertension are more likely to have a decreased VD after carteolol treatment. View Full-Text
Keywords: optical coherence tomography angiography; normal-tension glaucoma; vessel density; beta-blocker; carteolol; age; hypertension optical coherence tomography angiography; normal-tension glaucoma; vessel density; beta-blocker; carteolol; age; hypertension
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MDPI and ACS Style

Lin, Y.-H.; Huang, S.-M.; Chuang, L.-H.; Chen, L.-C. Retinal Vessel Density Changes on Optical Coherence Tomography Angiography and Predictive Factors in Normal-Tension Glaucoma Treated with Topical Beta-Blocker. Sci. Pharm. 2021, 89, 40. https://doi.org/10.3390/scipharm89030040

AMA Style

Lin Y-H, Huang S-M, Chuang L-H, Chen L-C. Retinal Vessel Density Changes on Optical Coherence Tomography Angiography and Predictive Factors in Normal-Tension Glaucoma Treated with Topical Beta-Blocker. Scientia Pharmaceutica. 2021; 89(3):40. https://doi.org/10.3390/scipharm89030040

Chicago/Turabian Style

Lin, Yun-Hsuan, Shih-Ming Huang, Lan-Hsin Chuang, and Lung-Chien Chen. 2021. "Retinal Vessel Density Changes on Optical Coherence Tomography Angiography and Predictive Factors in Normal-Tension Glaucoma Treated with Topical Beta-Blocker" Scientia Pharmaceutica 89, no. 3: 40. https://doi.org/10.3390/scipharm89030040

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