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Article

The Effect of Wheatgrass Lyophilizate on Blood Clotting Time in Rats

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Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, 6 Eötvös Street, H-6720 Szeged, Hungary
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Department of Pharmacognosy and Phytotherapy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureş, Gheorghe Marinescu Street 38, 540139 Târgu Mureş, Romania
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Interdisciplinary Centre for Natural Products, University of Szeged, 6 Eötvös Street, H-6720 Szeged, Hungary
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Department of Public Health, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary
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Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép Fasor 52, H-6726 Szeged, Hungary
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Department of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szikra Street 8, H-6725 Szeged, Hungary
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Author to whom correspondence should be addressed.
Academic Editors: Helen D. Skaltsa and Franz Bucar
Sci. Pharm. 2021, 89(3), 39; https://doi.org/10.3390/scipharm89030039
Received: 16 December 2020 / Revised: 12 August 2021 / Accepted: 12 August 2021 / Published: 20 August 2021
Wheatgrass is widely used in the alternative medicine, however, there is a lack of clinical evidence to support its efficacy. Although based on its chemical composition, data from animal experiments and clinical trials, the use of juice and extracts of Triticum shoots seems to be safe, clinical reports point out its potential interaction with oral anticoagulants. The aim of our study was to assess the interaction of wheatgrass with warfarin in rats and to assess its flavonoid content. Three groups of animals were treated orally with wheatgrass, warfarin, or the combination of wheatgrass and warfarin for five days. Clotting assays were performed using platelet-poor plasma. Prothrombin time was determined by optical and mechanical coagulometers. Flavonoid content of wheatgrass was measured by HPLC. The effect of wheatgrass on prothrombin time was not confirmed. Co-administration of wheatgrass and warfarin did not result in diminished anticoagulant activity. Low amount of flavonoids was detected in wheatgrass juice, the total flavonoid content was 0.467 mg/100 g lyophilized juice powder. The previously reported rutin, quercetin and apigenin was not detected by us. Our results do not confirm the probability of interaction of wheatgrass with oral anticoagulants. However, the low flavonoid content of wheatgrass does not support its use as an antioxidant. View Full-Text
Keywords: blood clotting; flavonoid; Triticum; warfarin; wheatgrass blood clotting; flavonoid; Triticum; warfarin; wheatgrass
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MDPI and ACS Style

Takács, I.; Urkon, M.; Kiss, T.; Horváth, E.; Laczkó-Zöld, E.; Zomborszki, Z.P.; Lukács, A.; Oszlánczi, G.; Csupor, D.; Szabó, A. The Effect of Wheatgrass Lyophilizate on Blood Clotting Time in Rats. Sci. Pharm. 2021, 89, 39. https://doi.org/10.3390/scipharm89030039

AMA Style

Takács I, Urkon M, Kiss T, Horváth E, Laczkó-Zöld E, Zomborszki ZP, Lukács A, Oszlánczi G, Csupor D, Szabó A. The Effect of Wheatgrass Lyophilizate on Blood Clotting Time in Rats. Scientia Pharmaceutica. 2021; 89(3):39. https://doi.org/10.3390/scipharm89030039

Chicago/Turabian Style

Takács, István, Melinda Urkon, Tivadar Kiss, Edina Horváth, Eszter Laczkó-Zöld, Zoltán P. Zomborszki, Anita Lukács, Gábor Oszlánczi, Dezső Csupor, and Andrea Szabó. 2021. "The Effect of Wheatgrass Lyophilizate on Blood Clotting Time in Rats" Scientia Pharmaceutica 89, no. 3: 39. https://doi.org/10.3390/scipharm89030039

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