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Review

The Chemistry and Pharmacology of Fungal Genus Periconia: A Review

by 1,2 and 1,3,*
1
Department of Chemistry, Faculty of Mathematic and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
2
Department of Chemistry Education, Faculty of Tarbiyah and Teacher Training, Institut Agama Islam Syekh Nurjati, Cirebon 45132, Indonesia
3
Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia
*
Author to whom correspondence should be addressed.
Academic Editor: Helen D. Skaltsa
Sci. Pharm. 2021, 89(3), 34; https://doi.org/10.3390/scipharm89030034
Received: 19 May 2021 / Revised: 25 June 2021 / Accepted: 5 July 2021 / Published: 29 July 2021
Periconia is filamentous fungi belonging to the Periconiaceae family, and over the last 50 years, the genus has shown interest in natural product exploration for pharmacological purposes. Therefore, this study aims to analyze the different species of Periconia containing natural products such as terpenoids, polyketides, cytochalasan, macrosphelides, cyclopentenes, aromatic compounds, and carbohydrates carbasugar derivates. The isolated compound of this kind, which was reported in 1969, consisted of polyketide derivatives and their structures and was determined by chemical reaction and spectroscopic methods. After some years, 77 compounds isolated from endophytic fungus Periconia were associated with eight plant species, 28 compounds from sea hare Aplysia kurodai, and ten from endolichenic fungi Parmelia sp. The potent pharmacological agents from this genus are periconicin A, which acts as an antimicrobial, pericochlorosin B as an anti-human immunodeficiency virus (HIV), peribysin D, and pericosine A as cytotoxic agents, and periconianone A as an anti-inflammatory agent. Furthermore, information about taxol and piperine from Periconia producing species was also provided. Therefore, this study supports discovering new drugs produced by the Periconia species and compares them for future drug development. View Full-Text
Keywords: natural product diversity; Periconia; Periconiaceae; pharmacological activities natural product diversity; Periconia; Periconiaceae; pharmacological activities
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MDPI and ACS Style

Azhari, A.; Supratman, U. The Chemistry and Pharmacology of Fungal Genus Periconia: A Review. Sci. Pharm. 2021, 89, 34. https://doi.org/10.3390/scipharm89030034

AMA Style

Azhari A, Supratman U. The Chemistry and Pharmacology of Fungal Genus Periconia: A Review. Scientia Pharmaceutica. 2021; 89(3):34. https://doi.org/10.3390/scipharm89030034

Chicago/Turabian Style

Azhari, Azmi, and Unang Supratman. 2021. "The Chemistry and Pharmacology of Fungal Genus Periconia: A Review" Scientia Pharmaceutica 89, no. 3: 34. https://doi.org/10.3390/scipharm89030034

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