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The Optimization of a Dimenhydrinate Transdermal Patch Formulation Based on the Quantitative Analysis of In Vitro Release Data by DDSolver through Skin Penetration Studies

Pharmaceutics Department, Dubai Pharmacy College for Girls, P.O. Box 19099-Dubai, Muhaisnah-1, Dubai, United Arab Emirates
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Academic Editor: Miklós Vecsernyés
Sci. Pharm. 2021, 89(3), 33; https://doi.org/10.3390/scipharm89030033
Received: 5 June 2021 / Revised: 28 June 2021 / Accepted: 12 July 2021 / Published: 16 July 2021
Dimenhydrinate is an over-the-counter medication that is used to relieve nausea, vomiting, and vertigo caused by motion sickness. It has a short elimination half-life, possibly due to its first-pass metabolism. The current study aimed to prepare and evaluate new transdermal formulations of dimenhydrinate to prolong the drug’s release and improve its cutaneous permeation. First, the patches were fabricated and evaluated to determine their properties. The results were statistically investigated and considered significant at the p < 0.05 level. Additionally, the quantitative analysis of the drug-release data and kinetic modeling was performed by using the DDSolver software to decide the candidate formula dependably. The effect of the penetration enhancers on the permeability of dimenhydrinate from the selected patch was then studied ex vivo compared to the control sample, and the patch’s safety was evaluated in rabbits, using the skin-irritation test. View Full-Text
Keywords: dimenhydrinate; transdermal; patch; skin permeation; penetration enhancers; DDSolver; in vitro release dimenhydrinate; transdermal; patch; skin permeation; penetration enhancers; DDSolver; in vitro release
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MDPI and ACS Style

Abdul Rasool, B.K.; Mohammed, A.A.; Salem, Y.Y. The Optimization of a Dimenhydrinate Transdermal Patch Formulation Based on the Quantitative Analysis of In Vitro Release Data by DDSolver through Skin Penetration Studies. Sci. Pharm. 2021, 89, 33. https://doi.org/10.3390/scipharm89030033

AMA Style

Abdul Rasool BK, Mohammed AA, Salem YY. The Optimization of a Dimenhydrinate Transdermal Patch Formulation Based on the Quantitative Analysis of In Vitro Release Data by DDSolver through Skin Penetration Studies. Scientia Pharmaceutica. 2021; 89(3):33. https://doi.org/10.3390/scipharm89030033

Chicago/Turabian Style

Abdul Rasool, Bazigha K., Amira A. Mohammed, and Yasmein Y. Salem 2021. "The Optimization of a Dimenhydrinate Transdermal Patch Formulation Based on the Quantitative Analysis of In Vitro Release Data by DDSolver through Skin Penetration Studies" Scientia Pharmaceutica 89, no. 3: 33. https://doi.org/10.3390/scipharm89030033

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