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Article

Characterization of Phytochemical Components of Crocus sativus Leaves: A New Attractive By-Product

1
Department of Pharmaceutical Chemistry, National University of Pharmacy, 4-Valentynivska st., 61168 Kharkiv, Ukraine
2
Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, A. Mickevičiaus g. 9, LT 44307 Kaunas, Lithuania
3
Department of Public Health, Dietetics and Lifestyle Disorders, Faculty of Medicine, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Helen D. Skaltsa
Sci. Pharm. 2021, 89(2), 28; https://doi.org/10.3390/scipharm89020028
Received: 15 May 2021 / Revised: 27 May 2021 / Accepted: 8 June 2021 / Published: 15 June 2021
(This article belongs to the Special Issue Feature Papers in Scientia Pharmaceutica)
Crocus sativus L. is one of the world’s most famous saffron production crops and its enormous by-products, such as leaves, are an excellent source of bioactive compounds with potential nutritional applications. The total phenolic content of Crocus leaves was 5.44 ± 0.01 mg GAE/g, and the total flavonoid content was 2.63 ± 0.05 mg RE/g, respectively. The main bioactive compounds in the leaves, such as polyphenols, flavonoids by HPLC and carboxylic acids, and amino acids, were also identified by GC-MS. HPLC analyses revealed mangiferin as a dominant constituent (1.26 ± 0.02 mg/g). C. sativus contains seven essential amino acids (ILE, LEU, LYS, MET, PHE, THR, TRP, VAL) in high concentration. Among them, isoleucine (7965 µg/g) was the dominant compound. In addition, the K and Ca concentrations in the leaves were significant (p < 0.05). The chemical composition revealed α-linolenic acid (22,490 µg/g) and linoelaidic acid (9880 µg/g) to be major constituents among all the acids found in the Crocus leaves. The extracts of C. sativus leaves showed the highest inhibitory activity for Gram-positive (B. subtilis and S. aureus) bacteria in the in vitro assay. The current results identify and underline the potential of natural products from C. sativus leaves that can add value to saffron production. View Full-Text
Keywords: Crocus sativus leaves; HPLC; UPLC-MS/MS; GC-MS; atomic emission spectroscopy; antibacterial assay; value-added byproducts Crocus sativus leaves; HPLC; UPLC-MS/MS; GC-MS; atomic emission spectroscopy; antibacterial assay; value-added byproducts
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MDPI and ACS Style

Mykhailenko, O.; Ivanauskas, L.; Bezruk, I.; Sidorenko, L.; Lesyk, R.; Georgiyants, V. Characterization of Phytochemical Components of Crocus sativus Leaves: A New Attractive By-Product. Sci. Pharm. 2021, 89, 28. https://doi.org/10.3390/scipharm89020028

AMA Style

Mykhailenko O, Ivanauskas L, Bezruk I, Sidorenko L, Lesyk R, Georgiyants V. Characterization of Phytochemical Components of Crocus sativus Leaves: A New Attractive By-Product. Scientia Pharmaceutica. 2021; 89(2):28. https://doi.org/10.3390/scipharm89020028

Chicago/Turabian Style

Mykhailenko, Olha, Liudas Ivanauskas, Ivan Bezruk, Lyudmila Sidorenko, Roman Lesyk, and Victoriya Georgiyants. 2021. "Characterization of Phytochemical Components of Crocus sativus Leaves: A New Attractive By-Product" Scientia Pharmaceutica 89, no. 2: 28. https://doi.org/10.3390/scipharm89020028

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