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Article

Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from Solidago virgaurea L. (Asteraceae)

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Department of Pharmaceutical Botany, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Gh. Marinescu, 400337 Cluj-Napoca, Romania
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Department of Pharmacology, Physiology, Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, 6A L. Pasteur, 400349 Cluj-Napoca, Romania
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National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, Romania
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Department of Pharmacognosy, Iuliu Hatieganu University of Medicine and Pharmacy, 12 I. Creanga, 400010 Cluj-Napoca, Romania
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Department of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hatieganu University of Medicine and Pharmacy, 41 V. Babes, 400012 Cluj-Napoca, Romania
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Author to whom correspondence should be addressed.
Academic Editor: Hermann Stuppner
Sci. Pharm. 2021, 89(2), 27; https://doi.org/10.3390/scipharm89020027
Received: 30 April 2021 / Revised: 3 June 2021 / Accepted: 9 June 2021 / Published: 14 June 2021
(This article belongs to the Special Issue Feature Papers in Scientia Pharmaceutica)
Solidago virgaurea L. is a perennial plant used in European traditional medicine as a diuretic or a remedy for inflammatory conditions of the urinary tract but also for gout, especially in the Balkans. The present study was focused on a preclinical, in vivo evaluation of antihyperuricemic, anti-inflammatory, and antihypertensive effects of a dry extract from S. virgaurea L. (ESV). Colorimetric and HPLC–MS techniques were used to identify the main chemical constituents of ESV. Antihyperuricemic effect of ESV was assessed in a rat model of hyperuricemia induced by the administration of potassium oxonate. Antihypertensive effect of ESV was evaluated in hyperuricemic rats by monitoring systolic blood pressure with a non-invasive blood-pressure recording system. The anti-inflammatory effect of ESV was tested using a rat model of paw edema. The main chemical constituents of ESV were rutin and phenolic acids represented by chlorogenic and caffeic acid. ESV demonstrated significant antihyperuricemic effects in rats due to an uricosuric mechanism. Additionally, ESV reduced the progression of arterial hypertension in hyperuricemic rats and also showed anti-inflammatory properties slightly inferior to diclofenac. The results suggest that ESV could be a natural remedy for the treatment of gout and protection against endothelial dysfunction caused by hyperuricemia. View Full-Text
Keywords: Solidago virgaurea L.; antihyperuricemic; anti-inflammatory; antihypertensive Solidago virgaurea L.; antihyperuricemic; anti-inflammatory; antihypertensive
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MDPI and ACS Style

Tămaş, M.; Vostinaru, O.; Soran, L.; Lung, I.; Opris, O.; Toiu, A.; Gavan, A.; Dinte, E.; Mogosan, C. Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from Solidago virgaurea L. (Asteraceae). Sci. Pharm. 2021, 89, 27. https://doi.org/10.3390/scipharm89020027

AMA Style

Tămaş M, Vostinaru O, Soran L, Lung I, Opris O, Toiu A, Gavan A, Dinte E, Mogosan C. Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from Solidago virgaurea L. (Asteraceae). Scientia Pharmaceutica. 2021; 89(2):27. https://doi.org/10.3390/scipharm89020027

Chicago/Turabian Style

Tămaş, Mircea, Oliviu Vostinaru, Loredana Soran, Ildiko Lung, Ocsana Opris, Anca Toiu, Alexandru Gavan, Elena Dinte, and Cristina Mogosan. 2021. "Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from Solidago virgaurea L. (Asteraceae)" Scientia Pharmaceutica 89, no. 2: 27. https://doi.org/10.3390/scipharm89020027

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