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Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 9 Lavrentiev Avenue, 630090 Novosibirsk, Russia
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Sci. Pharm. 2021, 89(1), 4; https://doi.org/10.3390/scipharm89010004
Received: 1 December 2020 / Revised: 21 December 2020 / Accepted: 23 December 2020 / Published: 29 December 2020
A series of triterpenic acid amides were synthesized incorporating a 2-ethoxy-3-phenylpropanoic acid pharmacophore fragment. The synthesized compounds were tested for their ability to improve glycemic control and to counter lipid abnormalities in C57BL/6 mice placed on a high-fat/high-cholesterol diet. Of all tested compounds, the dihydrobetulonic derivative (16b) had the most pronounced effect in decreasing blood glucose levels, total cholesterol (TC), and high-density lipoproteins (HDL). All the synthesized compounds displayed a relatively safe profile in the animal studies carried out in this work. View Full-Text
Keywords: type 2 diabetes mellitus; hypoglycemic activity; natural product; triterpenic amides; glucose tolerance; total cholesterol type 2 diabetes mellitus; hypoglycemic activity; natural product; triterpenic amides; glucose tolerance; total cholesterol
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MDPI and ACS Style

Fomenko, V.; Blokhin, M.; Kuranov, S.; Khvostov, M.; Baev, D.; Borisova, M.S.; Luzina, O.; Tolstikova, T.G.; Salakhutdinov, N.F. Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome. Sci. Pharm. 2021, 89, 4.

AMA Style

Fomenko V, Blokhin M, Kuranov S, Khvostov M, Baev D, Borisova MS, Luzina O, Tolstikova TG, Salakhutdinov NF. Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome. Scientia Pharmaceutica. 2021; 89(1):4.

Chicago/Turabian Style

Fomenko, Vladislav; Blokhin, Mikhail; Kuranov, Sergey; Khvostov, Mikhail; Baev, Dmitriy; Borisova, Marina S.; Luzina, Olga; Tolstikova, Tatyana G.; Salakhutdinov, Nariman F. 2021. "Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome" Sci. Pharm. 89, no. 1: 4.

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