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Open AccessReview

Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review

School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Korea
Author to whom correspondence should be addressed.
Sci. Pharm. 2017, 85(2), 21;
Received: 21 February 2017 / Revised: 25 April 2017 / Accepted: 25 April 2017 / Published: 28 April 2017
PDF [516 KB, uploaded 9 May 2017]


Angelica gigas Nakai is an important medicinal plant with health promoting properties that is used to treat many disorders. In traditional herbal medicine, the root of this plant is used to promote blood flow, to treat anemia, and is used as sedative or tonic agent. The root contains various bioactive metabolites; in particular, decursin and decursinol (pyranocoumarin type components) have been reported to possess various pharmacological properties. Recently, several in vitro and in vivo studies have reported that the crude extracts and isolated components from the root of A. gigas exhibited neuroprotective and cognitive enhancement effects. Neuronal damage or death is the most important factor for many neurodegenerative diseases. In addition, recent studies have clearly demonstrated the possible mechanisms behind the neuroprotective action of extracts/compounds from the root of A. gigas. In the present review, we summarized the neuroprotective and cognitive enhancement effects of extracts and individual compounds from A. gigas root. View Full-Text
Keywords: Angelica gigas; cognitive; decursin; neuroprotective; decursinol Angelica gigas; cognitive; decursin; neuroprotective; decursinol

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Sowndhararajan, K.; Kim, S. Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review. Sci. Pharm. 2017, 85, 21.

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