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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2015, 83(3), 445-452; (registering DOI)

Synthesis of Isomeric and Potent Impurities of the Triazole-Based Antifungal Drug Voriconazole

Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran (V), Medak Dist.-502329, Andhra Pradesh, India
Department of Engineering chemistry, Andhra University College of Engineering (A), Andhra University, Visakhapatnam-530003, Andhra Pradesh, India
Author to whom correspondence should be addressed.
Received: 25 January 2015 / Accepted: 6 March 2015 / Published: 6 March 2015
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We describe the synthesis of two positional isomers and a desfluoro impurity of Voriconazole starting with Friedel–Crafts acylation of mono- and difluoro-benzene. These isomers are the crucial components in determining the quality of Voriconazole during its manufacturing from the key raw material, 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one. All the prepared impurities were characterized by IR, 1H-NMR, 13C-NMR, and mass spectral data.
Keywords: Voriconazole; Impurity synthesis; Positional isomers; Chloroacetyl chloride Voriconazole; Impurity synthesis; Positional isomers; Chloroacetyl chloride
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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SUNDARAM, D.T.S.S.; MITRA, J.; ISLAM, A.; PRABAHAR, K.J.; VENKATESWARA RAO, B.; PAUL DOUGLAS, S. Synthesis of Isomeric and Potent Impurities of the Triazole-Based Antifungal Drug Voriconazole. Sci. Pharm. 2015, 83, 445-452.

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