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Volume 83
Issue 3
10.3797/scipharm.1503-10
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids

by
Mohammad F. HASSAN
1,
Abdul RAUF
1,*,
Asif SHERWANI
2 and
Mohammad OWAIS
2
1
Department of Chemistry, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
2
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(3), 429-443; https://doi.org/10.3797/scipharm.1503-10
Submission received: 22 March 2015 / Accepted: 9 June 2015 / Published: 9 June 2015
Versions Notes

Abstract

Herein we report saturated and unsaturated fatty acid derivatives of 1,3,4-oxadiazol-2(3H)-one and tetrahydropyridazine-3,6-dione as new potential anticancer agents. All the synthesised compounds were characterised by IR, 1H-NMR, 13C-NMR, and mass spectral data. The relative sensitivity of three cancer cell lines varied depending on the nature of the compound. Among the most effective anticancer compounds studied, 3b and 6b displayed remarkable anticancer activity against the MDA-MB-231 and KCL-22 lines, respectively. On the other hand, compound 3c was found to be most sensitive to nearly all the tested cell lines, MDA-MB-231, KCL-22, and HeLa.
Keywords: 1,3,4-Oxadiazol-2-one; Tetrahydropyridazine-3,6-dione; Fatty acids; Cytotoxicity; SAR 1,3,4-Oxadiazol-2-one; Tetrahydropyridazine-3,6-dione; Fatty acids; Cytotoxicity; SAR

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MDPI and ACS Style

HASSAN, M.F.; RAUF, A.; SHERWANI, A.; OWAIS, M. Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids. Sci. Pharm. 2015, 83, 429-443. https://doi.org/10.3797/scipharm.1503-10

AMA Style

HASSAN MF, RAUF A, SHERWANI A, OWAIS M. Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids. Scientia Pharmaceutica. 2015; 83(3):429-443. https://doi.org/10.3797/scipharm.1503-10

Chicago/Turabian Style

HASSAN, Mohammad F., Abdul RAUF, Asif SHERWANI, and Mohammad OWAIS. 2015. "Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids" Scientia Pharmaceutica 83, no. 3: 429-443. https://doi.org/10.3797/scipharm.1503-10

APA Style

HASSAN, M. F., RAUF, A., SHERWANI, A., & OWAIS, M. (2015). Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids. Scientia Pharmaceutica, 83(3), 429-443. https://doi.org/10.3797/scipharm.1503-10

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