Multivariate Image Analysis, Histogram Matching and Statistical Process Control Chart Assisted Nucleation Detection of Pharmaceutical Crystallization processes

L. L. SIMON; K. ABBOU OUCHERIF; Z. K. NAGY; K. HUNGERBUHLER

doi:10.3797/scipharm.cespt.8.PMS38

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12 July 2010

Multivariate Image Analysis, Histogram Matching and Statistical Process Control Chart Assisted Nucleation Detection of Pharmaceutical Crystallization processes

and

ETH Zurich, Institute of Chemical and Bioengineering, Zurich, Switzerland

New-Mexico Institute of Technology, Department of Chemical Engineering, Socorro, USA

Loughborough University, Chemical Engineering Department, Loughborough, United Kingdom

Author to whom correspondence should be addressed.

Sci. Pharm.2010, 78(3), 665;https://doi.org/10.3797/scipharm.cespt.8.PMS38

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Abstract

The aim of this work is to investigate image processing and process monitoring technologies which can provide a systematic, robust and sensitive solution for nucleation detection using bulk video imaging (BVI). [...]

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