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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2010, 78(1), 1-12; https://doi.org/10.3797/scipharm.0910-11

Studies on the Reactivity of (9-Methyl-5,6-dihydronaphtho[1',2':4,5]- thieno[2,3-d]pyrimidin-11-yl)hydrazine Towards Some Reagents for Biological Evaluation

1
Photochemistry Department, National Research Center, Elbehos Street, Dokki, Cairo, Egypt
2
Department of Natural and Microbial Products, National Research Center, Elbehos Street, Dokki, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 20 October 2009 / Accepted: 27 November 2009 / Published: 11 December 2009
PDF [205 KB, uploaded 26 September 2016]

Abstract

(9-Methyl-5,6-dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)hydrazine (1) was used as a precursor for preparation of some novel 1-(9-methyl-5,6- dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)-1H-pyrazoles 27, -1H-isoindole- 1,3(2H)-dione 8, and -pyridazin-3(2H)-one 9. Moreover, the acyclic C-nucleosides 10 and 11 were prepared by treating compound 1 with D-glucose. The in vitro antimicrobial activity of the tested compounds was evaluated by measuring the zone diameters and some of the prepared products showed potent antimicrobial activity in compared with those of well known drugs (standard). In general, the non-acetylated sugar hydrazone derivative 10 showed the highest antibacterial and antifungal potency among the tested compounds and standard with IZ = 22, 21 and 22 mm and MIC = 62.5 and 31.25 μg/ml, respectively.
Keywords: Thieno[2,3-d]pyrimidine; Pyrazole; Pyridazine; C-Nucleosides; Antimicrobial activity Thieno[2,3-d]pyrimidine; Pyrazole; Pyridazine; C-Nucleosides; Antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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RASHAD, A.E.; SHAMROUKH, A.H.; ABDEL-MEGEID, R.E.; SAYED, H.H.; ABDEL-WAHED, N.M. Studies on the Reactivity of (9-Methyl-5,6-dihydronaphtho[1',2':4,5]- thieno[2,3-d]pyrimidin-11-yl)hydrazine Towards Some Reagents for Biological Evaluation. Sci. Pharm. 2010, 78, 1-12.

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