Design and Synthesis of 23-Amino- 24,25,26,27-tetrakisnorlanosterolacetate and Derivatives as New Antimycotic Agents

GÖßNITZER, E.; PÖLZL, A.; WENDELIN, W.

doi:10.3797/scipharm.oephg.21.PO-23

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16 April 2009

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Design and Synthesis of 23-Amino- 24,25,26,27-tetrakisnorlanosterolacetate and Derivatives as New Antimycotic Agents

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Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University Graz, Schubertstraße 1, A-8010 Graz

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Sci. Pharm.2009, 77(7), 222;https://doi.org/10.3797/scipharm.oephg.21.PO-23

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Abstract

In search of new antimycotic agents acting as ergosterol biosynthesis inhibitors we investigated widely new and optimized reaction pathways for preparing different types of triazasteroids [1, 2]. The various mono-, bi-, tri- and tetracyclic triazasteroidal compounds are designed as stable aza-analogues of carbo-cationic high energy intermediates (HEIA) of fungal enzymes [1, 2].

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