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Sci. Pharm. 2009, 77(Posters (PO)), 220; https://doi.org/10.3797/scipharm.oephg.21.PO-21 (registering DOI)
Transport of NSAIDs across the Blood-Brain Barrier in vitro
Department of Medicinal Chemistry, University of Vienna, Pharmacy Center, Althanstraße 14, 1090 Vienna, Austria
PharmaCon GmbH, Riglergasse 4/5, 1180, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract The migration of substances between blood circulation and central nervous system (CNS) is regulated by the blood-brain barrier (BBB). Small lipophilic molecules such as carbon dioxide, oxygen or ethanol can pass the BBB by passive, transcellular diffusion, while the paracellular transport of hydrophilic substances is restricted by intercellular tight-junctions. Due to accessory transport systems the BBB is able to regulate specifically the permeation of substances (e.g. nutrients) .
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NOVAKOVA, I.; NEUHAUS, W.; SONNENBERG, M.; NOE, C.R. Transport of NSAIDs across the Blood-Brain Barrier in vitro. Sci. Pharm. 2009, 77, 220.
NOVAKOVA I, NEUHAUS W, SONNENBERG M, NOE CR. Transport of NSAIDs across the Blood-Brain Barrier in vitro. Scientia Pharmaceutica. 2009; 77(Posters (PO)):220.
NOVAKOVA, I.; NEUHAUS, W.; SONNENBERG, M.; NOE, C. R. 2009. "Transport of NSAIDs across the Blood-Brain Barrier in vitro." Sci. Pharm. 77, Posters (PO): 220.
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