Next Article in Journal
Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel
Previous Article in Journal
Preparation and In Vitro Evaluation of Budesonide Spray Dried Microparticles for Pulmonary Delivery
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle
Sci. Pharm. 2009, 77(2), 443-452; (registering DOI)

Development and Characterization of New Indomethacin Self-Nanoemulsifying Formulations

Department of Pharmaceutics, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
Received: 26 November 2008 / Accepted: 12 March 2009 / Published: 14 March 2009
PDF [348 KB, uploaded 21 December 2016]


In the present work a new indomethacin (IND) self-nanoemulsifying drug delivery formulation (SNEDDF) have been prepared to enhance its dissolution which in turn could provide a better chance for IND oral absorption. IND SNEDDF have been prepared using different concentrations of castor oil as a solvent for IND, Cremophor RH 40 (Cr-40) as surfactant and Capmul MCM-C8 (Ca-8) as co-surfactant. Droplets size and turbidity of IND SNEDDFs were measured. Dissolution profile of IND SNEDDFs filled in gelatin capsules was determined by using USP apparatus 2. Ternary phase diagram was constructed to identify the self-nanoemulsifying region after evaluation of IND SNEDDFs by the visual observation. The IND SNEDDFs were thermally characterized using differential scanning calorimetry (DSC) to ensure the compatibility among its ingredients. The present study revealed that the SNEDDFs increased IND dissolution rate and has the potential to enhance its bioavailability without interaction or incompatibility between the ingredients.
Keywords: Indomethacin; Nanoemulsion; DSC; SNEDDF; Dissolution Indomethacin; Nanoemulsion; DSC; SNEDDF; Dissolution
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

TAHA, E.I. Development and Characterization of New Indomethacin Self-Nanoemulsifying Formulations. Sci. Pharm. 2009, 77, 443-452.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics



[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top