Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC

Jan Šubert; Oldřich Fars; Marie Marečková

doi:10.3797/scipharm.2007.75.171

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Article

31 December 2007

Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC

and

nstitute of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic

Author to whom correspondence should be addressed.

Sci. Pharm.2007, 75(4), 171-178;https://doi.org/10.3797/scipharm.2007.75.171

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Abstract

HPLC was used to determine the content of methylparaben (MP), propylparaben (PP) and 4-hydroxybenzoic acid (4-HYB) as their decomposition product in the water solution Aqua Conservans (AQCO) in accordance with the Czech Pharmacopoeia and the Slovak Pharmaceutical Codex (0.067 % MP and 0.033 % PP). Based on the results of the analyses of 10 samples of AQCO from 8 pharmacies, 4-42 months after their preparation, an expiration period of 3 years was proposed for AQCO.

Keywords:

Parabens; Aqua Conservans; stability; 4-hydroxybenzoic acid; HPLC

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