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Sci. Pharm.
Volume 72
Issue 2
10.3797/scipharm.aut-04-11
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Article

IMPORTANCE OF THE OXIDATION REACTION OF SODIUM METAPERIODATE FOR SPECTROPHOTOMETRIC ASSAY OF RESERPINE

by
D. K. Singh
* and
Archana Sahu
Department of Chemistry, H. B. Technological Institute, Kanpur- 208 002, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(2), 121-129; https://doi.org/10.3797/scipharm.aut-04-11
Submission received: 11 November 2003 / Revised: 7 April 2004 / Accepted: 7 April 2004 / Published: 3 June 2004
Versions Notes

Abstract

A new simple, accurate and reasonably sensitive spectrophotometric method is described for the determination of reserpine based on the oxidation with sodium metaperiodate in the presence of acetic acid and coupling with 3-methyl-2-benzo thiazolinone hydazone hydrochloride (MBTH) to form highly blue coloured product showing maximum absorbance at 630 nm. Beer's law is obeyed in the range 0.2–1.6 µg ml−1. The relative standard deviation was found to be less than 1%. The proposed method can be applied for the estimation of reserpine in tablets with no evidence of interference from excipients.
Keywords: Reserpine; spectrophotometry; sodium metaperiodate; 3-methyl-2-benzo thiazolinone hydrazone hydrochloride Reserpine; spectrophotometry; sodium metaperiodate; 3-methyl-2-benzo thiazolinone hydrazone hydrochloride

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MDPI and ACS Style

Singh, D.K.; Sahu, A. IMPORTANCE OF THE OXIDATION REACTION OF SODIUM METAPERIODATE FOR SPECTROPHOTOMETRIC ASSAY OF RESERPINE. Sci. Pharm. 2004, 72, 121-129. https://doi.org/10.3797/scipharm.aut-04-11

AMA Style

Singh DK, Sahu A. IMPORTANCE OF THE OXIDATION REACTION OF SODIUM METAPERIODATE FOR SPECTROPHOTOMETRIC ASSAY OF RESERPINE. Scientia Pharmaceutica. 2004; 72(2):121-129. https://doi.org/10.3797/scipharm.aut-04-11

Chicago/Turabian Style

Singh, D. K., and Archana Sahu. 2004. "IMPORTANCE OF THE OXIDATION REACTION OF SODIUM METAPERIODATE FOR SPECTROPHOTOMETRIC ASSAY OF RESERPINE" Scientia Pharmaceutica 72, no. 2: 121-129. https://doi.org/10.3797/scipharm.aut-04-11

APA Style

Singh, D. K., & Sahu, A. (2004). IMPORTANCE OF THE OXIDATION REACTION OF SODIUM METAPERIODATE FOR SPECTROPHOTOMETRIC ASSAY OF RESERPINE. Scientia Pharmaceutica, 72(2), 121-129. https://doi.org/10.3797/scipharm.aut-04-11

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