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Sci. Pharm.
Volume 71
Issue 4
10.3797/scipharm.aut-03-29
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Article

In vitro Studies on Sustained Release Suppository Formulations of Tiaprofenic Acid with Sucrose Fattv Acid Ester †

by
Sevgi Gūngör
*,
Mine Orlu
,
Yildiz Özsoy
and
Ahmet Araman
Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Üniversite3 41 16, Istanbul, Turkey
*
Author to whom correspondence should be addressed.
†
This study was presented at 11th In ternational Pharmaceutical Technology Symposium, September, 9-1 1, 2002, Istanbul-Turkey.
Sci. Pharm. 2003, 71(4), 357-364; https://doi.org/10.3797/scipharm.aut-03-29
Submission received: 20 April 2003 / Revised: 28 October 2003 / Accepted: 28 October 2003 / Published: 15 December 2003
Versions Notes

Abstract

The objective of this study was to evaluate the performance of Sucro Ester 7 (sucrose distearate) as additive for preparing sustained release suppositories of tiaprofenic acid. Suppocire AIM (semi-synthetic glycerides) was used as suppository base and formulations were prepared containing different ratios of sugar ester: Suppocire AIM. Content uniformity, disintegration time and in vitro release characteristics of suppositories were investigated. Significant decrease in the extent of drug release was observed with the increase in the content of sugar ester, which was due to the longer disintegration time of suppositories.
Keywords: Tiaprofenic acid; sucrose fatty acid ester; sustained release suppository Tiaprofenic acid; sucrose fatty acid ester; sustained release suppository

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MDPI and ACS Style

Gūngör, S.; Orlu, M.; Özsoy, Y.; Araman, A. In vitro Studies on Sustained Release Suppository Formulations of Tiaprofenic Acid with Sucrose Fattv Acid Ester. Sci. Pharm. 2003, 71, 357-364. https://doi.org/10.3797/scipharm.aut-03-29

AMA Style

Gūngör S, Orlu M, Özsoy Y, Araman A. In vitro Studies on Sustained Release Suppository Formulations of Tiaprofenic Acid with Sucrose Fattv Acid Ester. Scientia Pharmaceutica. 2003; 71(4):357-364. https://doi.org/10.3797/scipharm.aut-03-29

Chicago/Turabian Style

Gūngör, Sevgi, Mine Orlu, Yildiz Özsoy, and Ahmet Araman. 2003. "In vitro Studies on Sustained Release Suppository Formulations of Tiaprofenic Acid with Sucrose Fattv Acid Ester" Scientia Pharmaceutica 71, no. 4: 357-364. https://doi.org/10.3797/scipharm.aut-03-29

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