Biosensor Using a One-Port Interdigital Capacitor: A Resonance-Based Investigation of the Permittivity Sensitivity for Microfluidic Broadband Bioelectronics Applications
Abstract
:1. Introduction
2. Biosensor Description and FEM Simulations
3. Equivalent-Circuit-Based Modeling and Sensitivity-Based Analysis
4. Modified Version of the Equivalent Circuit
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Reference | Channel-Electrode-Substrate Materials | Number of Ports | Volume | Analysis Method | Frequency Range | MUT |
---|---|---|---|---|---|---|
[34] | PDMS- Ti/Au- Quartz | 2 | 0.9 nL | FEM, EC parameters, and measurements | 40 MHz–40 GHz | Alcohol-based aqueous solutions and fetal bovine serum in water |
[47] | PDMS- Au- Quartz | 2 | <1 μL | FEM, EC parameters, and measurements | 100 Hz–40 GHz | De-ionized water and methanol |
[12] | PDMS- Au- Quartz | 1 | 1.2 nL | FEM and measurements | 7.8 GHz–8.4 GHz & @25 GHz | Water-isopropanol mixture |
[46] | SU-8- Au- Quartz | 2 | 0.1 μL | FEM, EC parameters, and measurements | 10 MHz–50 GHz | De-ionized water and saline solutions |
[28] | SU-8- Au- Quartz | 1 | 0.09 μL | FEM, EC parameters, and measurements | 300 kHz–50GHz | Yeast cell culture and mammalian cell culture |
[Here] | SU-8- Au- Quartz | 1 | 0.054 μL | FEM and EC parameters | 0.3 MHz–35 GHz | Lossless MUTs with different εr |
εr | fr (GHz) | Re(Y) @ fr (S) | C1 (fF) | R1 (Ω) |
---|---|---|---|---|
15 | 32.20 | 0.368 | 291.5 | 2.72 |
20 | 29.01 | 0.442 | 359.1 | 2.26 |
25 | 26.71 | 0.505 | 423.6 | 1.98 |
30 | 24.74 | 0.551 | 493.8 | 1.81 |
35 | 23.17 | 0.595 | 563.0 | 1.68 |
40 | 22.09 | 0.623 | 619.4 | 1.61 |
45 | 20.93 | 0.648 | 689.9 | 1.54 |
50 | 20.04 | 0.668 | 752.6 | 1.50 |
55 | 19.14 | 0.684 | 825.0 | 1.46 |
60 | 18.42 | 0.700 | 890.8 | 1.43 |
65 | 17.72 | 0.717 | 962.5 | 1.39 |
70 | 17.13 | 0.725 | 1030.0 | 1.38 |
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Crupi, G.; Bao, X.; Babarinde, O.J.; Schreurs, D.M.M.-P.; Nauwelaers, B. Biosensor Using a One-Port Interdigital Capacitor: A Resonance-Based Investigation of the Permittivity Sensitivity for Microfluidic Broadband Bioelectronics Applications. Electronics 2020, 9, 340. https://doi.org/10.3390/electronics9020340
Crupi G, Bao X, Babarinde OJ, Schreurs DMM-P, Nauwelaers B. Biosensor Using a One-Port Interdigital Capacitor: A Resonance-Based Investigation of the Permittivity Sensitivity for Microfluidic Broadband Bioelectronics Applications. Electronics. 2020; 9(2):340. https://doi.org/10.3390/electronics9020340
Chicago/Turabian StyleCrupi, Giovanni, Xiue Bao, Oluwatosin John Babarinde, Dominique M. M.-P. Schreurs, and Bart Nauwelaers. 2020. "Biosensor Using a One-Port Interdigital Capacitor: A Resonance-Based Investigation of the Permittivity Sensitivity for Microfluidic Broadband Bioelectronics Applications" Electronics 9, no. 2: 340. https://doi.org/10.3390/electronics9020340