Exploring AI in Healthcare Systems: A Study of Medical Applications and a Proposal for a Smart Clinical Assistant
Abstract
1. Introduction
- RQ1: How do we envision the next generation of intelligent clinical assistants integrating clinical decision-making workflows to autonomously analyze the adverse effects of combination medications while providing decision support to medical doctors?
- RQ2: What are the essential architectural elements and methodologies needed to create and execute a successful intelligent clinical support system?
- RQ3: What are the basic components of a framework that ensures the scalability and reliability of AI-based medical assistants, how has this concept evolved over time, and what is the potential of these assistants in modern healthcare systems?
2. Materials and Methods
2.1. MoodGYM
2.2. Woebot
2.3. Wysa
2.4. COVID-19 Canada Pediatric Chatbot
- Strengths:
- 60–70% reduction in triage time
- Reduced risk of exposure for medical staff
- Very high user satisfaction (parents, doctors)
- Easy to scale to other medical contexts
- Frees up medical personnel
- Limits COVID-19 exposure in waiting rooms
- Free, anonymous access
- High acceptability in hospital settings
- Weaknesses:
- Limited to a specific domain (COVID-19 screening)
- Requires strong integration with local IT infrastructure
- Does not perform complex diagnoses
- Depends on regular updates to medical guidelines
- Needs to be embedded within hospital systems
2.5. COVID-19 Symptom Evaluation Chatbot for India
- Strengths:
- Millions of users within a few months;
- Extremely fast and accurate automated triage (specificity >90%);
- Relieves pressure on medical personnel;
- Reduces hospital overcrowding;
- Provides verified official information;
- Linguistic adaptations for regional languages.
- Weaknesses:
- Focused on a single pathology (COVID-19);
- Requires continuous updates (medical guidelines);
- Initial challenges with regionalization and digital literacy;
- Controversies around privacy and personal data.
2.6. Platforms Selection Criteria and Metrics
- Geographic Diversity: Platforms were chosen to represent a range of regions and health system contexts, including high, middle, and low income settings, and both Western and non-Western digital health innovation;
- Technology Type Representation: The selection includes both chatbot based (Woebot, Wysa, COVID-19 chatbots) and non-chatbot (MoodGYM) digital health solutions, enabling comparison between conversational artificial intelligence and traditional digital interventions;
- Clinical Domain Coverage: Platforms address both chronic (mental health: Cognitive Behavioral Therapy, anxiety, depression) and acute (COVID-19 triage) care domains;
- Validation Level: Inclusion required peer reviewed evidence (randomized controlled trials, real-world studies, systematic reviews) or, for COVID-19 chatbots, documented operational impact and integration with healthcare systems.
2.7. Comparison and Analysis
- Platform name
- Type of digital intervention
- Objective/domain
- Target audience
- AI technology (yes/no and what type)
- Key benefits
- Major limitations
- Reported clinical outcomes
3. System Design and Workflow
3.1. Proposed System Architecture and Workflow
3.2. Proposed System Overview
- The frontend, representing the user interface, developed using the React library (based on the JavaScript language), which provides an interactive environment through which the doctor can access patient information and enter medical orders.
- The backend, built with NestJS (a Node.js framework based on the JavaScript language), forming a robust core that manages the application logic, data processing, and integration with external services.
- A centralized relational SQL database that stores all medical data, including patient records, hospitalized patients in each department, prescribed treatments, laboratory results, and appointments, ensuring data consistency and accessibility at the national level.
- An AI module (implemented in Python 3.13.0) integrated into the back end to provide decision support. This AI engine is responsible for analyzing prescribed treatments and laboratory results. A more detailed presentation of the AI module architecture and its evaluation follows in Section 3.4 and Section 3.5.
3.3. Operational Workflow for the Doctor
- Authentication in the system and display of patients;
- Selecting the patient and recording the initial data;
- Prescribing the initial treatment and verifying it with the help of the AI module;
- Requesting investigations and automatic scheduling;
- Receiving the results and interpreting them with the assistance of the AI module;
- Re-evaluating and adapting the treatment.
3.4. AI Module Architecture: Retrieval-Augmented Generation (RAG) Approach
3.5. AI Module Limitations, Ethical Considerations and Future Directions
3.6. Considerations on Research Questions
- The Data Perception Module is designed to aggregate and interpret clinical data from heterogeneous sources, including laboratory test results, EHRs, prescription data, and structured medical databases. This module employs advanced data integration techniques to harmonize disparate inputs into a unified, structured format. By transforming raw clinical information into standardized datasets, the system facilitates downstream analytical processes, enabling robust clinical decision support, predictive modeling, and research-driven insights.
- Knowledge-based reasoning engines, which examine data to find patterns in adverse events or possible drug interactions. These engines can use AI models for clinical reasoning, including large language models, machine learning (ML) classifiers, and knowledge graphs.
- Memory and Learning Components. These components interact with clinicians over time to improve prediction accuracy by learning from new cases and storing pertinent medical knowledge (such as medication databases and clinical guidelines).
- The Interaction and Integration Module functions as a communication interface between the clinical decision support system and medical personnel, ensuring alignment with established clinical practices. This module incorporates both a conversational agent and an interactive dashboard designed to elucidate system-generated alerts and recommendations. Furthermore, it provides integration capabilities with hospital IT infrastructures, enabling the suggestion of prescription adjustments and the formulation of patient monitoring plans. By facilitating transparent and actionable communication, the module enhances clinical workflow efficiency and supports informed decision-making. The SMA operates through interconnected modules that collect data before using AI reasoning to ensure medication safety and interact with users while following integration principles and security standards and maintainability protocols. The modular design with strict implementation will enable us to create an analysis system which performs effectively while being deployable in clinical environments and scalable between departments and hospitals and adaptable to upcoming requirements.
4. Discussion
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
Abbreviations
ADEs | Adverse Drug Events |
AI | Artificial Intelligence |
ANMDMR | National Agency for Medicines and Medical Devices of Romania |
API | Application Programming Interface |
BLEU | Bilingual Evaluation Understudy |
CBT | Cognitive Behavioral Therapy |
CDSS | Clinical Decision Support System |
EHR | Electronic Health Record |
EMR | Electronic Medical Record |
LIS | Laboratory Information System |
LLM | Large Language Model |
ML | Machine Learning |
NLP | Natural Language Processing |
RAG | Retrieval-Augmented Generation |
RBAC | Role-Based Access Control |
ROUGE | Recall-Oriented Understudy for Gisting Evaluation |
SMA | Smart Clinical Assistant |
SPC | Summaries of Product Characteristics |
SQL | Structured Query Language |
VPN | Virtual Private Network |
XAI | Explainable Artificial Intelligence |
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Platform | Geographic Origin | User Engagement Metrics | Clinical Efficacy Measures |
---|---|---|---|
MoodGYM | Australia/Europe | Over 1 million users, high dropout | Modest reduction in depression/anxiety (randomized controlled trials) |
Woebot | USA | 12.14 average sessions (randomized controlled trial), high engagement | Small-moderate reduction in depression/anxiety (Patient Health Questionnaire-9, Generalized Anxiety Disorder-7) |
Wysa | India/global | 10.9 average sessions (healthcare workers), 67.7% positive feedback | Modest reduction in depression/anxiety (Patient Health Questionnaire-9, Patient Health Questionnaire-4 |
COVID-19 pediatric chatbot | Canada | High parental satisfaction, rapid adoption | 60–70% reduction in triage time |
COVID-19 chatbot | India | Millions of users, rapid scale-up | Over 90% specificity in triage |
Characteristic | MoodGYM | Woebot | Wysa | Chabot COVID-19 Pediatrician | Chatbot COVID-19 India |
---|---|---|---|---|---|
Has chatbot | No | Yes | Yes | Yes | Yes |
Type of Digital Intervention | Self-guided modular app | Text-based CBT chatbot | Chatbot + journaling + exercises | Hospital-integrated chatbot | National self-assessment chatbot |
Objective/Domain | Mental health, depression prevention | Anxiety, depression | Psychological support for employees | COVID-19 screening | COVID-19 screening and triage |
Key Benefits | Accessible, scalable, low cost | Empathetic, 24/7, low cost | Anonymous, CBT technique combination | 60–70% triage time reduction, lower risk | Millions of users, >90% specificity |
Major Limitations | No personalization, low adherence | Small/moderate effects, limited adaptation | Pilot, modest effects, limited validation | Narrow domain, requires IT integration | Continuous updates, early localization issues |
AI/Chatbot | No | Basic conversational AI | Moderate conversational AI | Advanced conversational AI | Advanced conversational AI |
Reported Clinical Outcomes | Variable, sometimes small-moderate effects | Significant but small symptom reductions | Reduced anxiety/depression in pilot groups | Reduced triage time, high satisfaction | Reduced overcrowding, efficient triage |
Target Audience | Adolescents, adults (LMIC) | Adults | Corporate employees | Parents, children | General population (India) |
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Zota, R.D.; Cîmpeanu, I.A.; Lungu, M.A. Exploring AI in Healthcare Systems: A Study of Medical Applications and a Proposal for a Smart Clinical Assistant. Electronics 2025, 14, 3727. https://doi.org/10.3390/electronics14183727
Zota RD, Cîmpeanu IA, Lungu MA. Exploring AI in Healthcare Systems: A Study of Medical Applications and a Proposal for a Smart Clinical Assistant. Electronics. 2025; 14(18):3727. https://doi.org/10.3390/electronics14183727
Chicago/Turabian StyleZota, Răzvan Daniel, Ionuț Alexandru Cîmpeanu, and Mihai Adrian Lungu. 2025. "Exploring AI in Healthcare Systems: A Study of Medical Applications and a Proposal for a Smart Clinical Assistant" Electronics 14, no. 18: 3727. https://doi.org/10.3390/electronics14183727
APA StyleZota, R. D., Cîmpeanu, I. A., & Lungu, M. A. (2025). Exploring AI in Healthcare Systems: A Study of Medical Applications and a Proposal for a Smart Clinical Assistant. Electronics, 14(18), 3727. https://doi.org/10.3390/electronics14183727