Instrumental Evaluation of the Depigmenting Efficacy of an Oral Supplementation Containing Peptides and Chrysanthemum Extract for the Treatment of Melasma
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Test Product
2.3. Study Design
2.4. Reflectance Spectrophotometric Evaluation
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Group | Parameter | Percentage of Patients (Increase, %) | Percentage of Patients (Decrease, %) |
---|---|---|---|
Treatment group (n = 31) | L* | 96.77 | 3.23 |
a* | 48.39 | 51.61 | |
b* | 67.74 | 32.26 | |
ITA° | 96.77 | 3.23 | |
Placebo group (n = 31) | L* | 61.29 | 38.71 |
a* | 41.94 | 58.06 | |
b* | 83.87 | 16.13 | |
ITA° | 51.61 | 48.39 |
Group | Evaluation Time (n = 31) | Parameter | Variation (Delta) | p-Value |
---|---|---|---|---|
Treatment group (n = 31) | 30 days (D30–D0) | L* | 0.359 | 0.001 |
a* | 0.153 | 0.461 | ||
b* | 0.388 | 0.009 | ||
ITA° | 0.986 | 0.000 | ||
45 days (D45–D0) | L* | 0.754 | 0.000 | |
a* | 0.184 | 0.328 | ||
b* | 0.267 | 0.144 | ||
ITA° | 2.265 | 0.000 | ||
60 days (D60–D0) | L* | 1.246 | 0.000 | |
a* | −0.020 | 0.914 | ||
b* | 0.413 | 0.075 | ||
ITA° | 3.660 | 0.000 | ||
Placebo group (n = 31) | 30 days (D30–D0) | L* | 0.138 | 0.081 |
a* | −0.098 | 0.618 | ||
b* | 0.467 | 0.002 | ||
ITA° | 0.161 | 0.518 | ||
45 days (D45–D0) | L* | 0.163 | 0.112 | |
a* | −0.012 | 0.956 | ||
b* | 0.538 | 0.000 | ||
ITA° | 0.188 | 0.554 | ||
60 days (D60–D0) | L* | 0.196 | 0.093 | |
a* | −0.198 | 0.281 | ||
b* | 0.736 | 0.000 | ||
ITA° | 0.154 | 0.662 |
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Gui, M.; Kan, J.; Qu, D.; Chen, Y.; Luo, R.; Liu, Y.; Du, J. Instrumental Evaluation of the Depigmenting Efficacy of an Oral Supplementation Containing Peptides and Chrysanthemum Extract for the Treatment of Melasma. Cosmetics 2017, 4, 42. https://doi.org/10.3390/cosmetics4040042
Gui M, Kan J, Qu D, Chen Y, Luo R, Liu Y, Du J. Instrumental Evaluation of the Depigmenting Efficacy of an Oral Supplementation Containing Peptides and Chrysanthemum Extract for the Treatment of Melasma. Cosmetics. 2017; 4(4):42. https://doi.org/10.3390/cosmetics4040042
Chicago/Turabian StyleGui, Min, Juntao Kan, Di Qu, Yinbei Chen, Rong Luo, Yumin Liu, and Jun Du. 2017. "Instrumental Evaluation of the Depigmenting Efficacy of an Oral Supplementation Containing Peptides and Chrysanthemum Extract for the Treatment of Melasma" Cosmetics 4, no. 4: 42. https://doi.org/10.3390/cosmetics4040042
APA StyleGui, M., Kan, J., Qu, D., Chen, Y., Luo, R., Liu, Y., & Du, J. (2017). Instrumental Evaluation of the Depigmenting Efficacy of an Oral Supplementation Containing Peptides and Chrysanthemum Extract for the Treatment of Melasma. Cosmetics, 4(4), 42. https://doi.org/10.3390/cosmetics4040042