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Cosmetic Contact Allergens
Open AccessReview

Alternative Approach for Potency Assessment: In Vitro Methods

1
Laboratory of Toxicology, DiSFeB, Università degli Studi di Milano, Milan 20133, Italy
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3Rs Management and Consultancy, Kongens Lyngby 2800, Denmark
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Department Oral Cell Biology, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam 1081, The Netherlands
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Department Dermatology, VU University Medical Centre, Amsterdam 1081, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Cosmetics 2016, 3(1), 7; https://doi.org/10.3390/cosmetics3010007
Received: 7 January 2016 / Revised: 17 February 2016 / Accepted: 22 February 2016 / Published: 25 February 2016
(This article belongs to the Special Issue Cosmetic Contact Allergens)
Over the last decade, incredible progress has been made in the development of non-animal tests to assess contact hypersensitivity. Four methods have been successfully validated and Organisation for Economic Co-operation and Development (OECD) guidelines are available or soon will be. Currently validated methods are useful for hazard identification, classification and labeling. However, to achieve a complete replacement of animals in skin sensitization assessment, dose-response information and evaluation of relative skin sensitizing potency to support effective risk assessment are necessary. In this context, potency is based on the concentration of chemicals needed to induce a positive response. This will require a better understanding of the mechanisms determining potency, including pathway analysis and marker signature identification (selection of an appropriate immune-mediated response to serve as the basis), together with quantitative and qualitative correlations between marker signatures and potency of chemicals in relation with T cell responses. This review aims to discuss the state-of-the-art in the field of in vitro assessment of the no induction sensitization level of contact sensitizers. View Full-Text
Keywords: potency; allergy; keratinocytes; dendritic cells; in vitro immunotoxicology potency; allergy; keratinocytes; dendritic cells; in vitro immunotoxicology
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MDPI and ACS Style

Corsini, E.; Roggen, E.L.; Galbiati, V.; Gibbs, S. Alternative Approach for Potency Assessment: In Vitro Methods. Cosmetics 2016, 3, 7. https://doi.org/10.3390/cosmetics3010007

AMA Style

Corsini E, Roggen EL, Galbiati V, Gibbs S. Alternative Approach for Potency Assessment: In Vitro Methods. Cosmetics. 2016; 3(1):7. https://doi.org/10.3390/cosmetics3010007

Chicago/Turabian Style

Corsini, Emanuela; Roggen, Erwin L.; Galbiati, Valentina; Gibbs, Sue. 2016. "Alternative Approach for Potency Assessment: In Vitro Methods" Cosmetics 3, no. 1: 7. https://doi.org/10.3390/cosmetics3010007

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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