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Mechanistic Understanding of Contact Allergy

Can We Make Cosmetic Contact Allergy History?

DABMEB Consultancy Ltd, Sharnbrook, Bedfordshire MK44 1PR, UK
Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan 20133, Italy
Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Cosmetics 2016, 3(1), 11;
Received: 5 January 2016 / Revised: 17 February 2016 / Accepted: 18 February 2016 / Published: 1 March 2016
(This article belongs to the Special Issue Cosmetic Contact Allergens)
Chemical allergy is of considerable importance to the toxicologist, who, amongst other things, has the responsibility of identifying and characterizing the skin (and respiratory) sensitizing potential of chemicals, and estimating the risk they pose to human health. Allergic contact dermatitis (ACD) is to a large extent a preventable disease. Although quantitative risk assessment (QRA) for contact allergy can be performed, it is reasonable to ask why the burden of the skin disease ACD appears to remain stubbornly high, and in particular, that the general level of ACD to sensitizing ingredients found in cosmetics has not fallen noticeably over recent decades; some could argue that it has increased. In this review, this conundrum is addressed, considering whether and to what extent the prevalence of cosmetic allergy is truly unchanged, whether the predicted test methods and potency estimations are sufficiently precise and how proposed changes to the QRA process (i.e., cumulative exposure) may ameliorate the situation. Improved and more widespread use of risk assessment, better education of risk assessors, better post-marketing surveillance and monitoring of dermatology clinic feedback to improve QRA, all together could help to “make contact allergy history”. View Full-Text
Keywords: cosmetics; skin sensitization; contact allergy; allergic contract dermatitis; risk assessment cosmetics; skin sensitization; contact allergy; allergic contract dermatitis; risk assessment
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MDPI and ACS Style

Basketter, D.; Corsini, E. Can We Make Cosmetic Contact Allergy History? Cosmetics 2016, 3, 11.

AMA Style

Basketter D, Corsini E. Can We Make Cosmetic Contact Allergy History? Cosmetics. 2016; 3(1):11.

Chicago/Turabian Style

Basketter, David, and Emanuela Corsini. 2016. "Can We Make Cosmetic Contact Allergy History?" Cosmetics 3, no. 1: 11.

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