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Article

Lovage (Levisticum officinale W.D.J. Koch) Roots: A Source of Bioactive Compounds towards a Circular Economy

1
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
2
Departamento Acadêmico de Alimentos (DAALM), Universidade Tecnológica Federal do Paraná, Campus Medianeira, Paraná 85884-000, Brasil
3
REQUIMTE/LAQV, Faculdade de Farmácia, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
*
Authors to whom correspondence should be addressed.
Resources 2020, 9(7), 81; https://doi.org/10.3390/resources9070081
Received: 22 May 2020 / Revised: 23 June 2020 / Accepted: 24 June 2020 / Published: 30 June 2020
Lovage (Levisticum officinale W.D.J. Koch) is an aromatic plant from the Apiaceae (Umbelliferae) family used as a condiment in several regions of Europe and also described to have medicinal properties. While the aerial parts are used as foods, the roots are generally discarded. In the past, lovage roots were used in folk medicine for their diuretic, carminative, and spasmolytic properties. Therefore, the exploitation of this undervalued part of the plant can be a source of valuable bioactive compounds for food and/or pharmaceutical industries. Thus, in this study, extracts of different polarity were prepared and studied regarding their chemical composition and bioactive properties. To the best of our knowledge, the composition in phenolic compounds and the volatile profile of the n-hexane extract are reported for the first time. A total of 24 compounds were identified by GC-MS in the n-hexane extract, evidencing a high relative abundance of phthalides. A total of eight phenolic compounds were identified in lovage root extracts (decoction and hydroethanolic extract), with vanillic acid being the major compound. Regarding antioxidant activity, also reported for the first time, decoction and hydroethanolic extract exhibited a high antioxidant capacity in thiobarbituric acid reactive substances (TBARS) (179 ± 11 μg/mL) and in oxidative hemolysis (OxHLIA) assays (510 ± 6 μg/mL), respectively. n-Hexane extract showed relevant anti-proliferative activity against all tumor cell lines tested (GI50, 48–69 μg/mL), despite inhibiting also the growth of a non-tumoral hepatocyte cell line, however, presenting a significantly higher GI50 value (147 μg/mL). This study revealed that lovage root, an agri-food residue, can be a source of valuable bioactive compounds also presenting biological properties that deserve being explored, which could lead to a circular economy for food and/or the pharmaceutical industry. View Full-Text
Keywords: Levisticum officinale roots; phenolic compounds; phthalides; bioactivity; agri-food waste; circular economy Levisticum officinale roots; phenolic compounds; phthalides; bioactivity; agri-food waste; circular economy
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MDPI and ACS Style

Spréa, R.M.; Fernandes, Â.; Finimundy, T.C.; Pereira, C.; Alves, M.J.; Calhelha, R.C.; Canan, C.; Barros, L.; Amaral, J.S.; Ferreira, I.C.F.R. Lovage (Levisticum officinale W.D.J. Koch) Roots: A Source of Bioactive Compounds towards a Circular Economy. Resources 2020, 9, 81. https://doi.org/10.3390/resources9070081

AMA Style

Spréa RM, Fernandes Â, Finimundy TC, Pereira C, Alves MJ, Calhelha RC, Canan C, Barros L, Amaral JS, Ferreira ICFR. Lovage (Levisticum officinale W.D.J. Koch) Roots: A Source of Bioactive Compounds towards a Circular Economy. Resources. 2020; 9(7):81. https://doi.org/10.3390/resources9070081

Chicago/Turabian Style

Spréa, Rafael M., Ângela Fernandes, Tiane C. Finimundy, Carla Pereira, Maria J. Alves, Ricardo C. Calhelha, Cristiane Canan, Lillian Barros, Joana S. Amaral, and Isabel C.F.R. Ferreira. 2020. "Lovage (Levisticum officinale W.D.J. Koch) Roots: A Source of Bioactive Compounds towards a Circular Economy" Resources 9, no. 7: 81. https://doi.org/10.3390/resources9070081

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