Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity
Abstract
:1. Introduction
2. Experimental Section
2.1. Ethics Statement
2.2. Animals and Experimental Procedure
2.3. Assessment of Ovarian Activity
2.4. Evaluation of Metabolic Status
2.5. Evaluation of Fatty Acids Composition
2.6. Statistical Analysis
3. Results
3.1. Changes in Body Mass and Adiposity
3.2. Changes in Metabolic Status
3.3. Changes in Fatty Acid Composition of Adipose Tissues (Subcutaneous and Visceral Fat)
3.4. Changes in Fatty Acid Composition of Non-Adipose Tissues (Muscle and Liver)
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Tissue | Layer/Fraction | Variable (g/100 g) | CON | MEN |
---|---|---|---|---|
SCF | Out | C16:1n-9 | 0.34 a ± 0.02 | 0.30 b ± 0.01 |
C22:4n-6 | 0.06 a ± 0.00 | 0.07 b ± 0.00 | ||
C22:6n-3 | 0.01 c ± 0.00 | 0.02 d ± 0.00 | ||
DN6 | 0.01 a ± 0.00 | 0.01 b ± 0.00 | ||
In | C16:1n-7 | 2.28 c ± 0.12 | 1.87 d ± 0.12 | |
C20:5n-3 | 0.01 a ± 0.00 | 0.01 b ± 0.00 | ||
C22:4n-6 | 0.05 c ± 0.00 | 0.06 d ± 0.00 | ||
C22:6n-3 | 0.01 c ± 0.00 | 0.02 d ± 0.00 | ||
DN3 | 0.02 a ± 0.00 | 0.02 b ± 0.00 | ||
VF | C14:0 | 1.43 c ± 0.06 | 1.21 d ± 0.06 | |
C16:0 | 28.0 c ± 0.36 | 26.8 d ± 0.45 | ||
C16:1n-9 | 0.38 c ± 0.02 | 0.31 d ± 0.02 | ||
C16:1n-7 | 1.94 a ± 0.14 | 1.54 b ± 0.12 | ||
C18:1n-9 | 36.7 c ± 0.33 | 38.4 d ± 0.54 | ||
C18:2n-6 | 10.7 a ± 0.41 | 9.82 b ± 0.26 | ||
MUFA | 43.4 c ± 0.21 | 44.5 d ± 0.52 | ||
LD | Polar | MUFA | 23.5 c ± 0.20 | 22.5 d ± 0.34 |
Liver | Neutral | C18:1n-7 | 1.72 a ± 0.16 | 2.11 b ± 0.06 |
C20:5n-3 | 0.18 a ± 0.02 | 0.14 b ± 0.01 | ||
C22:6n-3 | 0.85 e ± 0.08 | 1.24 f ± 0.03 | ||
∑n3 | 1.89 a ± 0.17 | 2.23 b ± 0.07 |
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Heras-Molina, A.; Pesantez-Pacheco, J.L.; Vazquez-Gomez, M.; Garcia-Contreras, C.; Astiz, S.; Isabel, B.; Gonzalez-Bulnes, A. Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity. Biology 2020, 9, 284. https://doi.org/10.3390/biology9090284
Heras-Molina A, Pesantez-Pacheco JL, Vazquez-Gomez M, Garcia-Contreras C, Astiz S, Isabel B, Gonzalez-Bulnes A. Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity. Biology. 2020; 9(9):284. https://doi.org/10.3390/biology9090284
Chicago/Turabian StyleHeras-Molina, Ana, José Luis Pesantez-Pacheco, Marta Vazquez-Gomez, Consolacion Garcia-Contreras, Susana Astiz, Beatriz Isabel, and Antonio Gonzalez-Bulnes. 2020. "Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity" Biology 9, no. 9: 284. https://doi.org/10.3390/biology9090284