A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer
Abstract
:1. Introduction
2. p53 and Brain Development
3. p53 and Neural Stem Cell Regulation
4. p53 and Brain Cancer
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Mouse Models | p53-Dependent Brain Developmental Phenotypes | p53 Status |
---|---|---|
p53−/− [13,14] | Female-specific exencephaly, spina bifida, retinal dysplasia | p53 deletion |
p53N236S/N236S [22] | Female specific exencephaly and spina bifida | p53 missense mutation |
p53−/−; Bim+/− [26] | 100% penetrate, female-exclusive exencephaly | p53 deletion |
Pax3Sp/Sp [33] | Exencephaly | p53 stabilization |
Mdm2FM/+; Nestin-Cre [35] | Hydranencephaly | p53 stabilization |
Mdm4FX/+; Nestin-Cre [35] | Porencephaly | p53 stabilization |
Nbnflox/flox; Nestin-Cre [36] | Microcephaly | p53 stabilization |
Nde1−/− [37] | Microcephaly | p53 stabilization |
Cep63T/T [38] | Microcephaly | p53 stabilization |
Tubb5E401K/E401K; Nestin-Cre [39] Tubb5flox/+; Nestin-Cre [39] | Microcephaly | p53 stabilization |
Eif4a3flox/+; Emx1-Cre [40] | Microcephaly | p53 stabilization |
Rbm8aflox/+; Emx1-Cre [40] | Microcephaly | p53 stabilization |
Magohflox/+; Emx1-Cre [40] | Microcephaly | p53 stabilization |
CitK−/− [41] | Microcephaly | p53 stabilization |
Kif20bm/m [42] | Microcephaly | p53 stabilization |
AspmSA/SA [43] Aspmflox/flox; Math1-Cre [43] | Microcephaly (hypoplastic cerebellum) | p53 stabilization |
p53515C/515C; Mdm2−/− [44] | Cerebellar defects | Mutant p53 stabilization |
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Xiong, Y.; Zhang, Y.; Xiong, S.; Williams-Villalobo, A.E. A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer. Biology 2020, 9, 285. https://doi.org/10.3390/biology9090285
Xiong Y, Zhang Y, Xiong S, Williams-Villalobo AE. A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer. Biology. 2020; 9(9):285. https://doi.org/10.3390/biology9090285
Chicago/Turabian StyleXiong, Yuqing, Yun Zhang, Shunbin Xiong, and Abie E. Williams-Villalobo. 2020. "A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer" Biology 9, no. 9: 285. https://doi.org/10.3390/biology9090285