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Oxidative Stress in Reproduction: A Mitochondrial Perspective

Eugin, 08006 Barcelona, Spain
Centro de Infertilidad y Reproducción Humana (CIRH), 08006 Barcelona, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biology 2020, 9(9), 269;
Received: 2 August 2020 / Revised: 31 August 2020 / Accepted: 2 September 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Oxidative Stress in Gametes and Embryos)
Mitochondria are fundamental organelles in eukaryotic cells that provide ATP through oxidative phosphorylation. During this process, reactive oxygen species (ROS) are produced, and an imbalance in their concentrations can induce oxidative stress (OS), causing cellular damage. However, mitochondria and ROS play also an important role in cellular homeostasis through a variety of other signaling pathways not related to metabolic rates, highlighting the physiological relevance of mitochondria–ROS interactions. In reproduction, mitochondria follow a peculiar pattern of activation, especially in gametes, where they are relatively inactive during the initial phases of development, and become more active towards the final maturation stages. The reasons for the lower metabolic rates are attributed to the evolutionary advantage of keeping ROS levels low, thus avoiding cellular damage and apoptosis. In this review, we provide an overview on the interplay between mitochondrial metabolism and ROS during gametogenesis and embryogenesis, and how OS can influence these physiological processes. We also present the possible effects of assisted reproduction procedures on the levels of OS, and the latest techniques developed to select gametes and embryos based on their redox state. Finally, we evaluate the treatments developed to manage OS in assisted reproduction to improve the chances of pregnancy. View Full-Text
Keywords: reactive oxygen species; oxidative stress; mitochondria; gametogenesis; assisted reproduction reactive oxygen species; oxidative stress; mitochondria; gametogenesis; assisted reproduction
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MDPI and ACS Style

Almansa-Ordonez, A.; Bellido, R.; Vassena, R.; Barragan, M.; Zambelli, F. Oxidative Stress in Reproduction: A Mitochondrial Perspective. Biology 2020, 9, 269.

AMA Style

Almansa-Ordonez A, Bellido R, Vassena R, Barragan M, Zambelli F. Oxidative Stress in Reproduction: A Mitochondrial Perspective. Biology. 2020; 9(9):269.

Chicago/Turabian Style

Almansa-Ordonez, Alexandra, Raquel Bellido, Rita Vassena, Montserrat Barragan, and Filippo Zambelli. 2020. "Oxidative Stress in Reproduction: A Mitochondrial Perspective" Biology 9, no. 9: 269.

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