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Open AccessArticle

Lymphoid Tissue in Teleost Gills: Variations on a Theme

1
Department of Biosciences, University of Oslo, Blindernveien 31, 0371 Oslo, Norway
2
Section of Anatomy, Faculty of Veterinary Science, Norwegian University of Life Sciences, Ullevålsveien 72, 0454 Oslo, Norway
3
Zoology and Evolutionary Biology, University of Basel, 4051 Basel, Switzerland
4
Aquaculture and Fisheries Group, Department of Animal Sciences, Wageningen University & Research, 6700 AH Wageningen, The Netherlands
5
University of Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France
6
Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University & Research, 6700 AH Wageningen, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Present address: Pharmaq Analytiq, Thormøhlens Gate 53D, 5008 Bergen, Norway.
Biology 2020, 9(6), 127; https://doi.org/10.3390/biology9060127
Received: 4 May 2020 / Revised: 7 June 2020 / Accepted: 12 June 2020 / Published: 15 June 2020
In bony fish, the gill filaments are essential for gas exchanges, but also are vulnerable to infection by water-borne microorganisms. Omnipresent across fish, gill-associated lymphoid tissues (GIALT) regulate interactions with local microbiota and halt infection by pathogens. A special GIALT structure has recently been found in Salmonids, the interbranchial lymphoid tissue (ILT). However, the structural variation of GIALT across bony fish remains largely unknown. Here, we show how this critical zone of interaction evolved across fishes. By labeling a conserved T-cell epitope on tissue sections, we find that several basal groups of teleosts possess typical ILT, while modern teleosts have lymphoepithelium of different shape and size at the base of primary gill filaments. Within Cypriniformes, neither body size variation between two related species, zebrafish and common carp, nor morphotype variation, did have a drastic effect on the structure of ILT. Thereby this study is the first to describe the presence of ILT in zebrafish. The ILT variability across fish orders seems to represent different evolutionary solutions to balancing trade-offs between multiple adaptations of jaws and pharyngeal region, and immune responses. Our data point to a wide structural variation in gill immunity between basal groups and modern teleosts. View Full-Text
Keywords: fish; gills; ilt; evolution; zap70 fish; gills; ilt; evolution; zap70
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Rességuier, J.; Dalum, A.S.; Du Pasquier, L.; Zhang, Y.; Koppang, E.O.; Boudinot, P.; Wiegertjes, G.F. Lymphoid Tissue in Teleost Gills: Variations on a Theme. Biology 2020, 9, 127.

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